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Filtering by: Creator Jayaraman, A. Remove constraint Creator: Jayaraman, A. Committee Member Alani, Adam Remove constraint Committee Member: Alani, Adam Resource Type Dissertation Remove constraint Resource Type: Dissertation

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  • Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

    Creator:
    DuRoss, Allison N.
    Abstract:
    The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
    Resource Type:
    Dissertation
    Full Text:
    nanoparticles, however, represent only a small class of nanomaterials that may be impactful in the field of

  • Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

    Creator:
    Kim, Jeonghwan
    Abstract:
    Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
    Resource Type:
    Dissertation
    Full Text:
    the murine nasal cavity. Next, we tried to stabilize LNPs during aerosolization by a