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Filtering by: Creator Sukhatme, Gaurav S. Remove constraint Creator: Sukhatme, Gaurav S. Committee Member Alani, Adam Remove constraint Committee Member: Alani, Adam

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  • Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

    Creator:
    Kim, Jeonghwan
    Abstract:
    Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
    Resource Type:
    Dissertation
    Full Text:
    Therapeutics Abstract approved: ______________________________________________________ Gaurav

  • Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

    Creator:
    Sabei, Fahad Yahya
    Abstract:
    Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...
    Resource Type:
    Dissertation
    Full Text:
    would like to thank all of my committee members, Drs. Adam Alani, Gaurav Sahay, Jung Kwon for their

  • Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

    Creator:
    Albarqi, Hassan Ahmad M.
    Abstract:
    Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
    Resource Type:
    Dissertation
    Full Text:
    Alani, Gaurav Sahay, and Ling Jin for serving on my thesis committee and their guidance. Special

  • Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

    Creator:
    DuRoss, Allison N.
    Abstract:
    The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
    Resource Type:
    Dissertation
    Full Text:
    , Dr. Gaurav Sahay, and Dr. Jerry Jaboin, thank you for always attending meetings ready to provide

  • A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

    Creator:
    Schumann, Canan B.
    Abstract:
    Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
    Resource Type:
    Dissertation
    Full Text:
    diagnosed ovarian cancer cases and usually but not always affects the younger women (early 20’s) [20