Search Constraints

Start Over
Filtering by: Alternative title ssim EM 8348 Remove constraint Alternative title ssim: EM 8348 Committee Member Anderson, Sonia Remove constraint Committee Member: Anderson, Sonia

Search Results

  • Characterization of neuronal nitric-oxide synthase reductase activity

    Creator:
    Wolthers, Kirsten R.
    Abstract:
    During catalysis the flavoprotein domain of neuronal nitric-oxide synthase (nNOS) shuttles NADPH-derived reducing equivalents from FAD to FMN and then to the P450-heme enabling heme-based oxygen activation and subsequent NO-synthesis. The binding of Ca²⁺-activated calmodulin (Ca²⁺-CaM) to nNOS alleviates inhibition of flavin mediated electron transfer within the diflavin domain, which...
    Resource Type:
    Dissertation