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Filtering by: Subject Nuclear structure Committee Member Baham, John

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:

Yang, Liping

Abstract:

The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....

Resource Type:

Dissertation

Full Text:

The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription