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Filtering by: Creator Kuriyama, Y. Remove constraint Creator: Kuriyama, Y. Committee Member Baird, William M. Remove constraint Committee Member: Baird, William M.

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Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:

You, Hyekyoung Hannah

Abstract:

Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...

Resource Type:

Honors College Thesis

Full Text:

272 (30): 18702–8. Shimada, T., and Y. Fujii-Kuriyama. 2004. “Metabolic Activation of Polycyclic
Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:

Castro, David J.

Abstract:

Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...

Resource Type:

Dissertation

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systems upon metabolic activation to chemically reactive species (Shimada and Fujii-Kuriyama, 2004
Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:

Courter, Lauren A.

Abstract:

Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...

Resource Type:

Dissertation

Full Text:

. Washington D.C.: American Chemical Society, 1985. 12. Wood, A. W., Levin, W., Lu, A. Y., Yagi, H

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Academic Affiliation

Environmental and Molecular Toxicology2

Advisor

Williams, David E.2
Baird, William M.1

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2007 to 2016

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Committee Member

Baird, William M.[remove]3
Buermeyer, Andrew1
Field, Kate1
Harding, Anna1
Ho, Emily1
more Committee Members »

Creator

Castro, David J.1
Courter, Lauren A.1
You, Hyekyoung Hannah1

Date

Date range begin – Date range end

Current results range from 2007 to 2016

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Decade

2010-20191
2000-20092

Degree Field

Toxicology2
BioResource Research1

Degree Level

Doctoral2
Bachelor's1

Degree Name

Doctor of Philosophy (Ph.D.)2
Honors Bachelor of Science (H.B.S.)1

File Format

application/pdf1

Language

English [eng]3

License

All rights reserved3

Non-Academic Affiliation

Oregon State University. Graduate School2
Oregon State University. Bioresource Research1
Oregon State University. Honors College1

Peer Reviewed

No3

Resource Type

Dissertation2
Honors College Thesis1

Rights Statement

In Copyright3

Subject

Benzopyrene -- Carcinogenicity2
Cancer -- Chemoprevention1
Chemical carcinogenesis1
Chlorophyllin -- Health aspects1
Polycyclic aromatic hydrocarbons -- Carcinogenicity1

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