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Filtering by: Creator Alapisco, Dawn Marie Committee Member Barbar, Elisar

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:

Otto, Shauna C.

Abstract:

Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...

Resource Type:

Dissertation
Viral Targeting of Host Hubs: Interactions between the Rabies Virus and LC8

Creator:

Jespersen, Nathan E.

Abstract:

As obligate intracellular parasites, viruses rely on host machinery for their own reproduction. Viruses are therefore required to interact with a wide variety of host proteins, despite limitations in viral genome size. The most parsimonious method of success is to hijack central and essential proteins, known as hub proteins. LC8...

Resource Type:

Dissertation

Full Text:

Jamin, Jeam-Marie Bourhis, and Francine Gérard contributed to SAXS data collection and analysis in