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Filtering by: Subject Time-of-flight mass spectrometry Remove constraint Subject: Time-of-flight mass spectrometry Committee Member Barofsky, Douglas F. Remove constraint Committee Member: Barofsky, Douglas F. Degree Level Doctoral Remove constraint Degree Level: Doctoral

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  • Alkylation of peptides and proteins by S-(2-chloroethyl)glutathione and characterization of adducts by mass spectrometry

    Creator:
    Erve, John C. L.
    Abstract:
    Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...
    Resource Type:
    Dissertation
    Full Text:
    ultraviolet (Beavis and Chait, 1990). Time of flight mass spectrometers are the ideal mass analyzers when

  • Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

    Creator:
    Wang, Jing
    Abstract:
    Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
    Resource Type:
    Dissertation
    Full Text:
    commonly used mass analyzers in this field include the quadrupole (Q), ion trap (IT), time-of-flight (TOF