Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Subject Glutathione Committee Member Barofsky, Douglas F. Subject Glutathione

Alkylation of peptides and proteins by S-(2-chloroethyl)glutathione and characterization of adducts by mass spectrometry

Creator:

Erve, John C. L.

Abstract:

Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...

Resource Type:

Dissertation

Full Text:

and Proteins by S-(2-chloroethyl) glutathione and Characterization of Adducts by Mass Spectrometry