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Filtering by: Creator Doucette, John Committee Member Barofsky, Douglas F.

The detection of superoxide and implications for amyotrophic lateral sclerosis

Creator:

Robinson, Kristine M.

Abstract:

Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the selective death of motor neurons that characterizes ALS. Nitric oxide competes effectively with superoxide dismutase for superoxide to form the powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...

Resource Type:

Dissertation