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Filtering by: Creator Gharib, Camron I. Committee Member Beckman, Joseph S. Decade 2010-2019

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Creator:

Gómez Ramirez, Luis A.

Abstract:

Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...

Resource Type:

Dissertation

Full Text:

supercomplexes comprised of various stoichiometries of complexes I, III and IV (never complex II), which