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Filtering by: Committee Member Blakemore, Paul R. Committee Member Blakemore, Paul Decade 2000-2009

Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis

Creator:

Carlson, Erik

Abstract:

Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...

Resource Type:

Masters Thesis

Full Text:

extend my appreciation to my committee members, Prof. Paul R. Blakemore, Prof. Kevin P. Gable, Prof
Studies towards the total syntheses of (+)-phomactins A, D and G

Creator:

Schwartz, Keith D.

Abstract:

Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....

Resource Type:

Dissertation

Full Text:

members, Professor Rich G. Carter, Professor Paul R. Blakemore, Professor Philip J. Proteau and
Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Creator:

Tonsiengsom, Sorasaree

Abstract:

Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...

Resource Type:

Dissertation

Full Text:

devoted to this research study. I would also like to thank Drs. Max Deinzer, Kevin Gable, Paul Blakemore