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Filtering by: Creator Gilbert, Erin H. Remove constraint Creator: Gilbert, Erin H. Committee Member Blakemore, Paul Remove constraint Committee Member: Blakemore, Paul Degree Field Chemistry Remove constraint Degree Field: Chemistry

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  • New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

    Creator:
    Overacker, Ross D.
    Abstract:
    Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
    Resource Type:
    Dissertation
    Full Text:
    level inhibition (∼7 µM) of HIV-1 by acting on the RNase H activity of the viral reverse transcriptase

  • Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

    Creator:
    Ferreira, Andrew
    Abstract:
    The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...
    Resource Type:
    Dissertation
    Full Text:
    conformation. Our curiosity was a result of the observation that there HO arundarine N H NMe2 N HO MeHN

  • Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

    Creator:
    Brumsted, Corey J.
    Abstract:
    Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
    Resource Type:
    Dissertation
    Full Text:
    ); (G) DMSO; (H) cells…………………………………….………………………………………………..……….............………….150 Figure 4.13

  • Studies toward the total synthesis of sanglifehrin A

    Creator:
    Suttisintong, Khomson
    Abstract:
    Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
    Resource Type:
    Dissertation
    Full Text:
    . J.; Quesniaux, V.; Fehr, T.; Hofmann, H.; Mahnke, M.; Memmert, K.; Schuler, W.; Zenke, G