Search Constraints

Start Over
Filtering by: Committee Member Blakemore, Paul R. Remove constraint Committee Member: Blakemore, Paul R. Committee Member Blakemore, Paul Remove constraint Committee Member: Blakemore, Paul Degree Level Doctoral Remove constraint Degree Level: Doctoral

Search Results

  • Racemic and Enantioselective Synthesis of Cavicularin

    Creator:
    Zhao, Peng
    Abstract:
    This dissertation describes the racemic and enantioselective synthesis cavicularin. Cavicularin is a macrocyclic bisbibenzyls family member natural product. It has been an attractive synthetic target due to its intriguing structure: the macrocyclic core imparts sufficient strain on the system to force one benzene rings to adopt a boat-shaped conformation, out...
    Resource Type:
    Dissertation

  • Studies towards the total syntheses of (+)-phomactins A, D and G

    Creator:
    Schwartz, Keith D.
    Abstract:
    Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
    Resource Type:
    Dissertation
    Full Text:
    members, Professor Rich G. Carter, Professor Paul R. Blakemore, Professor Philip J. Proteau and

  • Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

    Creator:
    Salih, M. Quamar
    Abstract:
    Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
    Resource Type:
    Dissertation
    Full Text:
    !committee,!Prof.!Paul!Blakemore,!Prof.!Paul!Cheong,!Prof.!Kerry!McPhaill! and!Prof.!Steve!Giovanini! for

  • A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

    Creator:
    Points, Gary L., III
    Abstract:
    Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
    Resource Type:
    Dissertation
    Full Text:
    formation of a new carbon bond ortho to the R-substituent on the aryl ring is disfavored due to steric

  • Outliers: The Unusual Characteristics of Marine Carbon-Oxidizing Bacterial Cells Adapted to Oligotrophic Conditions

    Creator:
    Noell, Stephen E.
    Abstract:
    Oligotrophic bacteria are adapted to low nutrient concentrations. As most of the ocean is oligotrophic (low in nutrients), oligotrophic bacteria thrive in the ocean and make up the majority of planktonic cells. Because of this, oligotrophs are crucial to oceanic nutrient cycles. However, marine oligotrophic bacteria are dwarfed by their...
    Resource Type:
    Dissertation
    Full Text:
    . Paul Blakemore, Allen Milligan, Ryan Mueller, and Martin Schuster, for their helpful feedback, input

  • A Computational Method for Building Spherical Pictures and Theoretic Results from Explicit Constructions

    Creator:
    Merzenich, Matthias C.
    Abstract:
    Let H be a cyclically-presented group on n generators with a single defining relator. Attempts have been made to classify such groups by their order, their status as a 3-manifold group, and the asphericity status of their presentations. For groups with a defining relator of length 3 these classifications are...
    Resource Type:
    Dissertation
    Full Text:
    〉 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 2.5 (i) and (ii) vertices (discs) representing r and r−1. (iii) A dipole is formed when these

  • New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

    Creator:
    Overacker, Ross D.
    Abstract:
    Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
    Resource Type:
    Dissertation
    Full Text:
    positivity, hard work, and determination are a model for all. I would like to thank Paul Blakemore for

  • Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

    Creator:
    Adpressa, Donovon A.
    Abstract:
    Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
    Resource Type:
    Dissertation
    Full Text:
    serving on my committee with very little consultation or notice. Prof. Paul Blakemore, thank you for the

  • Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

    Creator:
    Ferreira, Andrew
    Abstract:
    The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...
    Resource Type:
    Dissertation
    Full Text:
    , 14, 1-81. 2 Adams, R.; Yuan, H. C. Chem. Rev. 1933, 12, 261–338

  • Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

    Creator:
    Brumsted, Corey J.
    Abstract:
    Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
    Resource Type:
    Dissertation