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Filtering by: Committee Member Blakemore, Paul R. Remove constraint Committee Member: Blakemore, Paul R. Committee Member Blakemore, Paul Remove constraint Committee Member: Blakemore, Paul Non-Academic Affiliation Oregon State University. Graduate School Remove constraint Non-Academic Affiliation: Oregon State University. Graduate School

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Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:

Snyder, Kevin M.

Abstract:

In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...

Resource Type:

Masters Thesis

Full Text:

Synthesis Abstract approved: ______________________________________________________ Paul Ha
Racemic and Enantioselective Synthesis of Cavicularin

Creator:

Zhao, Peng

Abstract:

This dissertation describes the racemic and enantioselective synthesis cavicularin. Cavicularin is a macrocyclic bisbibenzyls family member natural product. It has been an attractive synthetic target due to its intriguing structure: the macrocyclic core imparts sufficient strain on the system to force one benzene rings to adopt a boat-shaped conformation, out...

Resource Type:

Dissertation
Progress Towards the Total Synthesis of Bazzanin K

Creator:

Salvo, Patrick

Abstract:

Molecular chirality plays a critical role in chemistry, biology, and medicine. To study and better understand conformational chirality, it is necessary to obtain structurally interesting molecules that exhibit this form of chirality. Our lab utilizes total synthesis and methodological development to obtain conformationally chiral natural products of interest. We believe...

Resource Type:

Masters Thesis

Full Text:

. 5 B. S. Moore, J. L. Chen, G. M. L. Patterson, R. E. Moore, L. S. Brinen, Y. Kato, and J. Clardy, J
Terahertz transmission & spectroscopy of vertically grown multi-walled carbon nanotube forests

Creator:

Maizy, Louis

Abstract:

In this thesis, I present studies in the field of terahertz [THz] spectroscopy. It covers both the generation and detection of ultra-fast broadband THz pulses, as well as the transmission properties of vertically grown multi-walled carbon nanotube forests [MWCNTs]. We have found that these vertically grown MWCNTs respond strongly to...

Resource Type:

Masters Thesis

Full Text:

. Finally, to my prede- cessors Andy Jameson, Joe Tomaino, and Michael Paul, for sharing their knowledge
Improvements in synthesis and response techniques of ion-selective sensors

Creator:

Pylypiuk, Nataliia

Abstract:

Two improvements to the established procedures for synthesis and response detection of ion-selective optical sensors (optodes) were introduced. The first improvement addresses the drawback of organic dye (optode-localized chromoionophore) photobleaching. This positively impacts fluorescence response and allows for (1) direct measurement of hydrogen ion activity upon binding with the dye,...

Resource Type:

Masters Thesis

Full Text:

commitment of my graduate committee members: Kim Anderson, Paul Blakemore and Christopher Beaudry
Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis

Creator:

Carlson, Erik

Abstract:

Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...

Resource Type:

Masters Thesis

Full Text:

extend my appreciation to my committee members, Prof. Paul R. Blakemore, Prof. Kevin P. Gable, Prof
Studies towards the total syntheses of (+)-phomactins A, D and G

Creator:

Schwartz, Keith D.

Abstract:

Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....

Resource Type:

Dissertation

Full Text:

members, Professor Rich G. Carter, Professor Paul R. Blakemore, Professor Philip J. Proteau and
Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Creator:

Salih, M. Quamar

Abstract:

Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...

Resource Type:

Dissertation

Full Text:

!committee,!Prof.!Paul!Blakemore,!Prof.!Paul!Cheong,!Prof.!Kerry!McPhaill! and!Prof.!Steve!Giovanini! for
Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

Creator:

Ferreira, Andrew

Abstract:

The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...

Resource Type:

Dissertation

Full Text:

, 14, 1-81. 2 Adams, R.; Yuan, H. C. Chem. Rev. 1933, 12, 261–338
Programming of Furosemide Pharmacokinetics by Intrauterine Growth Restriction and High Fat Diet in the Adult Rat

Creator:

DuBois, Barent Nathan

Abstract:

Perinatal growth restriction programs higher risk for chronic disease during adulthood via morphological and physiological changes in organ systems. Perinatal growth restriction is highly correlated with a decreased nephron number, altered renal function and subsequent hypertension. I hypothesize that such renal maladaptations result in altered pharmacologic patterns for life. Pregnant...

Resource Type:

Dissertation

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Academic Affiliation

Chemistry14
Physics2
College of Pharmacy1

Advisor

Carter, Rich G.3
Beaudry, Chris2
Beaudry, Christopher2
Lee, Yun Shik2
White, James2
more Advisors »

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2007 to 2018

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Committee Member

Blakemore, Paul[remove]17
Carter, Rich6
Gable, Kevin5
McPhail, Kerry3
Minot, Ethan2
more Committee Members »

Creator

Carlson, Erik1
Collett, Nathan D.1
Dubois, Barent Nathan1
Ferreira, Andrew1
Jameson, Andrew D.1
more Creators »

Date

Date range begin – Date range end

Current results range from 2006 to 2017

View distribution

Decade

2010-201914
2000-20093

Degree Field

Chemistry14
Physics2
Pharmacy1

Degree Level

Doctoral12
Master's5

Degree Name

Doctor of Philosophy (Ph.D.)12
Master of Science (M.S.)5

File Format

application/pdf1

Language

English [eng]17

License

All rights reserved15

Non-Academic Affiliation

Oregon State University. Graduate School[remove]17

Peer Reviewed

No16

Resource Type

Dissertation12
Masters Thesis5

Rights Statement

In Copyright17

Subject

Alkaloids -- Synthesis3
Chirality2
Enantioselective catalysis2
Natural products -- Synthesis2
Terahertz spectroscopy2
more Subjects »

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