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  • Studies Toward the Synthesis of Natural Product Scaffolds

    Creator:
    Lusk, Jason S.
    Abstract:
    Part 1: A Diels-Alder Approach to the Synthesis of Novel Analogues of the Natural Product Siamenol Due to the prevalence of biaryl motifs in natural product synthesis, the Carter research group has been exploring the utility of a Diels-Alder approach to biaryl synthesis. The Diels-Alder approach involves a [4+2] cycloaddition...
    Resource Type:
    Honors College Thesis
    Full Text:
    ______________________________________________________________________ Paul Blakemore, Committee Member, representing Synthetic Organic Chemistry

  • Evaluation of Bacterial F1FO-ATPase Inhibitors for Synergistic Effects

    Creator:
    Heppe, Kenan G.
    Abstract:
    F1FO-ATP synthase targeting antimicrobials apoptolidin 1 (A1), (+)-erythromefloquine, and oligomycin were tested in vitro for synergistic minimum inhibitory concentrations against Staphylococcus aureus. Synergy was strictly defined as inhibition by at most 25% the MIC of each participating drug. Ampicillin, with an MIC of 0.8 ug/mL, served as a negative control....
    Resource Type:
    Honors College Thesis
    Full Text:
    the towel. Dr. Paul Blakemore, no matter how busy, always made time to answer my questions. His

  • Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

    Creator:
    Snyder, Kevin M.
    Abstract:
    In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
    Resource Type:
    Masters Thesis
    Full Text:
    Synthesis Abstract approved: ______________________________________________________ Paul Ha

  • Racemic and Enantioselective Synthesis of Cavicularin

    Creator:
    Zhao, Peng
    Abstract:
    This dissertation describes the racemic and enantioselective synthesis cavicularin. Cavicularin is a macrocyclic bisbibenzyls family member natural product. It has been an attractive synthetic target due to its intriguing structure: the macrocyclic core imparts sufficient strain on the system to force one benzene rings to adopt a boat-shaped conformation, out...
    Resource Type:
    Dissertation

  • Progress Towards the Total Synthesis of Bazzanin K

    Creator:
    Salvo, Patrick
    Abstract:
    Molecular chirality plays a critical role in chemistry, biology, and medicine. To study and better understand conformational chirality, it is necessary to obtain structurally interesting molecules that exhibit this form of chirality. Our lab utilizes total synthesis and methodological development to obtain conformationally chiral natural products of interest. We believe...
    Resource Type:
    Masters Thesis
    Full Text:
    . 5 B. S. Moore, J. L. Chen, G. M. L. Patterson, R. E. Moore, L. S. Brinen, Y. Kato, and J. Clardy, J

  • Terahertz transmission & spectroscopy of vertically grown multi-walled carbon nanotube forests

    Creator:
    Maizy, Louis
    Abstract:
    In this thesis, I present studies in the field of terahertz [THz] spectroscopy. It covers both the generation and detection of ultra-fast broadband THz pulses, as well as the transmission properties of vertically grown multi-walled carbon nanotube forests [MWCNTs]. We have found that these vertically grown MWCNTs respond strongly to...
    Resource Type:
    Masters Thesis
    Full Text:
    . Finally, to my prede- cessors Andy Jameson, Joe Tomaino, and Michael Paul, for sharing their knowledge

  • Improvements in synthesis and response techniques of ion-selective sensors

    Creator:
    Pylypiuk, Nataliia
    Abstract:
    Two improvements to the established procedures for synthesis and response detection of ion-selective optical sensors (optodes) were introduced. The first improvement addresses the drawback of organic dye (optode-localized chromoionophore) photobleaching. This positively impacts fluorescence response and allows for (1) direct measurement of hydrogen ion activity upon binding with the dye,...
    Resource Type:
    Masters Thesis
    Full Text:
    commitment of my graduate committee members: Kim Anderson, Paul Blakemore and Christopher Beaudry

  • Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis

    Creator:
    Carlson, Erik
    Abstract:
    Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...
    Resource Type:
    Masters Thesis
    Full Text:
    extend my appreciation to my committee members, Prof. Paul R. Blakemore, Prof. Kevin P. Gable, Prof

  • Studies towards the total syntheses of (+)-phomactins A, D and G

    Creator:
    Schwartz, Keith D.
    Abstract:
    Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
    Resource Type:
    Dissertation
    Full Text:
    members, Professor Rich G. Carter, Professor Paul R. Blakemore, Professor Philip J. Proteau and

  • Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

    Creator:
    Salih, M. Quamar
    Abstract:
    Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
    Resource Type:
    Dissertation
    Full Text:
    !committee,!Prof.!Paul!Blakemore,!Prof.!Paul!Cheong,!Prof.!Kerry!McPhaill! and!Prof.!Steve!Giovanini! for