Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Quinn, Alexander Committee Member Blakemore, Paul

Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

Creator:

Adpressa, Donovon A.

Abstract:

Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...

Resource Type:

Dissertation

Full Text:

.; Grkovic, T.; Ahmed, S.; Quinn, R.; Hentschel, U.; Edrada-Ebel, R. Mar. Drugs 2014, 12, 1220. 23
New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Creator:

Overacker, Ross D.

Abstract:

Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...

Resource Type:

Dissertation

Full Text:

-Werner and Alexander Herrmann performed and analyzed the fully infectious HIV neutralization assays
Outliers: The Unusual Characteristics of Marine Carbon-Oxidizing Bacterial Cells Adapted to Oligotrophic Conditions

Creator:

Noell, Stephen E.

Abstract:

Oligotrophic bacteria are adapted to low nutrient concentrations. As most of the ocean is oligotrophic (low in nutrients), oligotrophic bacteria thrive in the ocean and make up the majority of planktonic cells. Because of this, oligotrophs are crucial to oceanic nutrient cycles. However, marine oligotrophic bacteria are dwarfed by their...

Resource Type:

Dissertation

Full Text:

, Dr. Eric Moore, Michelle Michelsen, Quinn Washburn, Greg Barrell, Sarah Wolf, Omran Muslin, and