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Filtering by: Creator Reilly, Paul Committee Member Blakemore, Paul

Rationalization and innovative design of asymmetric organocatalysts through computational investigation

Creator:

Johnston, Ryne Connell

Abstract:

My work on computing complex catalyzed organic transformations reveals that only a few subtle chemical factors, e.g. non-classical hydrogen bonding, (hyper)conjugation and steric effects, common across different catalyst manifolds are critical for catalysis and selectivity. Rational manipulation and exploitation of these factors has led to improved catalyst designs, which has...

Resource Type:

Dissertation

Full Text:

Organocatalysts through Computational Investigation. Abstract approved: Paul Ha-Yeon Cheong
Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Creator:

Tonsiengsom, Sorasaree

Abstract:

Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...

Resource Type:

Dissertation

Full Text:

devoted to this research study. I would also like to thank Drs. Max Deinzer, Kevin Gable, Paul Blakemore
New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Creator:

Overacker, Ross D.

Abstract:

Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...

Resource Type:

Dissertation

Full Text:

positivity, hard work, and determination are a model for all. I would like to thank Paul Blakemore for