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Filtering by: Alternative title ssim 4-H 962 Remove constraint Alternative title ssim: 4-H 962 Committee Member Blakemore, Paul R. Remove constraint Committee Member: Blakemore, Paul R. Committee Member Gable, Kevin P. Remove constraint Committee Member: Gable, Kevin P.

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  • Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

    Creator:
    Shaw, Subrata
    Abstract:
    This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
    Resource Type:
    Dissertation
    Full Text:
    Thalidomide (1) (R)-antiemetic (S)-teratogenic MeO Ni,_ ( -.I) ' N CI H Nexium (4) racemic: Prilosec OH H

  • A Diels-Alder approach to biaryl synthesis

    Creator:
    Ashburn, Bradley O.
    Abstract:
    An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...
    Resource Type:
    Dissertation
    Full Text:
    provide increased potency. 4 EtO O NSAID - Antiarthritic (1.8) N CO2H O N N N H N