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Filtering by: Creator Sikkel, Paul C. Remove constraint Creator: Sikkel, Paul C. Committee Member Blakemore, Paul R. Remove constraint Committee Member: Blakemore, Paul R. Committee Member McPhail, Kerry L. Remove constraint Committee Member: McPhail, Kerry L.

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  • Biosynthesis and modification of the antibiotic enduracidin

    Creator:
    Goebel, Neal C.
    Abstract:
    The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
    Resource Type:
    Dissertation
    Full Text:
    OF Neal C. Goebel for the degree of Doctor of Philosophy in Pharmacy presented on December 13

  • Strategies for the Synthesis of Nitrogeous Compounds : Aminal Radical Reaction and Pyridinium Oxide Cycloadditions

    Creator:
    Lu, Yi
    Abstract:
    Pharmaceuticals, molecular catalysts, and secondary metabolites often contain nitrogen. The problems faced synthesizing compounds which contain nitrogen was because of the Lewis base reactivity of nitrogen lone pairs, and the acidic protons of some nitrogenous functional groups. We developed two methods for the synthesis of nitrogeous compounds. Additionally, we successfully...
    Resource Type:
    Dissertation

  • A Diels-Alder approach to biaryl synthesis

    Creator:
    Ashburn, Bradley O.
    Abstract:
    An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...
    Resource Type:
    Dissertation
    Full Text:
    , O and P for the phosphorus series and N, Cl/Br, O and C for the carbonyl and tertiary alcohol

  • Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

    Creator:
    Serrill, Jeffrey D.
    Abstract:
    Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
    Resource Type:
    Dissertation
    Full Text:
    A and C are macrolide secondary metabolites produced by an actinomycete isolated from Indonesian