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Filtering by: Creator Miller, Scott W. Remove constraint Creator: Miller, Scott W. Committee Member Blakemore, Paul R. Remove constraint Committee Member: Blakemore, Paul R. Degree Field Chemistry Remove constraint Degree Field: Chemistry

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  • Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

    Creator:
    Shaw, Subrata
    Abstract:
    This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
    Resource Type:
    Dissertation
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    References 1. Livesey, G.; Brown, J. C. J. Nutr. 1995, 125, 3020. 2. Raymer, G. S.; Hartman, D. E.; Rowe, W

  • Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to indole and oxindole

    Creator:
    Li, Yang
    Abstract:
    Irradiation of a tryptamine linked through its side-chain nitrogen to an alkylidene malonate residue results in an intramolecular [2 + 2] cycloaddition to the indole 2,3-double bond. The resultant cyclobutane undergoes spontaneous retro-Mannich fission to produce a spiro[indoline-3,3-pyrrolenine] with relative configuration defined by the orientation of substituents in the transient...
    Resource Type:
    Dissertation
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    , 278 and 360. 5. Eaton, P. E.; Hurt, W. S. J. Am. Chem. Soc. 1966, 88, 5038. 6. Corey, E. J.; Bass

  • Polymeric submicron optical ion-selective sensors

    Creator:
    Bychkova, Valeriya
    Abstract:
    Ion-selective polymeric optical sensors – ion optodes – are a promising alternative to ion-selective electrodes and fluorescent dyes for analytical and biological applications, e.g. extra- and intracellular measurements. They are non-toxic, highly selective robust probes for ionic fluxes monitoring. A large-scale fabrication of ion optodes using a solvent displacement method...
    Resource Type:
    Dissertation
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    - Chemistry 1997, 38, 8-12. (4) Tan, W. H. S., Z.Y., Smith, S., Birnbaum, D., Kopelman, R. Science 1992

  • Expanding the scope of a Diels-Alder approach to biaryl synthesis

    Creator:
    Schwartz, Johanna Perkins
    Abstract:
    A Diels-Alder approach to biaryls (DAB) has been applied towards the synthesis of highly substituted, programmable biaryl templates. Tri- and tetra-ortho-substituted biaryls can be produced in just three to four steps from commercially available materials utilizing the Diels-Alder [4+2] cycloaddition. The methods described herein will illustrate the ability of mono...
    Resource Type:
    Dissertation
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    : Asymmetry 2002, 13,37. (c) Brunel, J. M. Chem. Rev. 2008, 108, 1170. 3. Dagne, E.; Steglich, W

  • Part I: Synthetic Studies Toward Mandelalide A and Madeirolide A; Part II: Synthesis of Mandelalide/Madeirolide Hybrid Structures

    Creator:
    Li, Jinming
    Abstract:
    Mandelalide A has attracted considerable interest from the synthetic community due to its intriguing structure and important cytotoxic activity. Madeirolide A, a structurally related macrolide, shows promising antifungal activity but no appreciable anticancer activity. This dissertation describes synthetic studies toward mandelalide A, madeirolide A and their hybrid structures. Part I...
    Resource Type:
    Dissertation
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    .; Lievens, S. L.; Saludes, J. P. Nat. Rev. Drug Discovery 2009, 8, 69. (b) Hughes, C. C.; Fenical, W. Chem

  • Dynamics and Design of Green Fluorescent Protein-Inspired Superphotoacids and Red-Emitting Fluorophores with Transient Absorption and Femtosecond Stimulated Raman Spectroscopy

    Creator:
    Chen, Cheng
    Abstract:
    In the past decades, femtosecond stimulated Raman spectroscopy (FSRS) has been gaining tremendous popularity in fundamental sciences stemming from chemistry to biology. It is capable of capturing both equilibrium and non-equilibrium structural information across a broad range of timescales with simultaneously high temporal and spectral resolutions. Femtosecond transient absorption spectroscopy...
    Resource Type:
    Dissertation

  • Studies toward the total synthesis of (+)-providencin

    Creator:
    Jana, Somnath
    Abstract:
    Studies toward the total synthesis of (+)-providencin (1), a highly oxygenated cembranoid dipterpene with a unique bicyclo[12.2.0]hexadecane skeleton and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 320 and 332 which contain all of the carbon atoms of 1. In a first generation approach...
    Resource Type:
    Dissertation
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    . 4. (a) Abramson, S. N.; Trischman, J. A.; Tapiolas, D. M.; Harold, E. E.; Fenical, W.; Taylor, P

  • A unified approach for the total synthesis of C₁₀-functionalyzed Lycopodium alkaloids

    Creator:
    Saha, Mrinmoy
    Abstract:
    Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
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    Dissertation
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    1985, 26, 241-296. (c) Ayer, W. A. Nat. Prod. Rep., 1991, 8, 455-463. (d) Ayer, W. A.; Trfonov, L. S

  • Studies towards the total synthesis of (-)-kendomycin

    Creator:
    Smits, Helmars
    Abstract:
    Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
    Resource Type:
    Dissertation
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    protected as the corresponding acetonide 91. The primary benzyl ether of 91 was cleaved using W-2 Raney

  • Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

    Creator:
    Vellucci, Jessica K.
    Abstract:
    Aminal radical intermediates were generated by the method of radical translocation and reacted in C-C bond forming reactions with electronically deficient alkenes (Schiedler et al. Org. Lett. 2012, 14, 6092). Aminal radical intermediates can participate in inter- and intra-molecular reactions using both Bu3SnH and (TMS)₃SiH as hydride donors. Carbon–carbon bonds...
    Resource Type:
    Dissertation
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    .; Parsons, W. H.; Du Bois, J. Angew. Chem. Int. Ed. 2014, 53, 5760. For a review of palau’amine, see: Köck