Index Catalog // ScholarsArchive@OSU

Total Synthesis of Cephalotaxus Alkaloids and Synthetic Studies toward Bazzanin K

Creator:: Ju, Xuan
Abstract:: Dearomatization reactions exist broadly in biosynthesis and chemical synthesis. The highly functionalized atoms of arenes can be masked by it aromaticity, and upon dearomatization, those reactive atoms can be readily applied to bond formation and further manipulation. The total synthesis of (–)-cephalotaxine and (–)- homoharringtonine is described via an oxidative...
Resource Type:: Dissertation
Full Text:: . K. J. Am. Chem. Soc. 1954, 76, 4749–4751. 10 Martin, D. B. C.; Vanderwal, C. D. Chem. Sci. 2011, 2

Part I: Synthetic Studies Towards Viridin, Halenaquinone, and Obtusanal. Part II: Analysis, Synthesis, and Characterization of Coronene Derivatives.

Creator:: Waldenmaier, Pieter K.
Abstract:: This thesis is separated into three distinct projects. First, synthetic studies towards the furanosteroid viridin shown in part I. Second, synthetic studies towards the diperene obtusanal shown in part II. Third, the analysis, characterization, and synthesis of coronene derivatives towards their application in organic batteries shown in part III. Significant...
Resource Type:: Dissertation
Full Text:: .; Siripong, P.; Tip-Pyang, S., Nat. Prod. Research, 2006, 20, 1321 - 1321. 3 Abbas, H. K.; Mirocha, C. J

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Creator:: Vellucci, Jessica K.
Abstract:: Aminal radical intermediates were generated by the method of radical translocation and reacted in C-C bond forming reactions with electronically deficient alkenes (Schiedler et al. Org. Lett. 2012, 14, 6092). Aminal radical intermediates can participate in inter- and intra-molecular reactions using both Bu3SnH and (TMS)₃SiH as hydride donors. Carbon–carbon bonds...
Resource Type:: Dissertation
Full Text:: .; Chakraborty, T. K.; Piscopio, A. D.; Minowa, N.; Bertinato, P. J. Am. Chem. Soc. 1993, 115, 4419. (b) Ge, H

Bioprospecting the Chemical Diversity of Plant-associated Fungi

Creator:: González-Montiel, Gisela Abigail
Abstract:: Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and...
Resource Type:: Masters Thesis
Full Text:: (500 MHz, CDCl3) δ 12.49 (s, 1H, 5-OH, 5’-OH), 7.31 (d, 1H, J=8.7 Hz, 6-CH, 6’-CH), 7.24 (d, 1H, J

Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to indole and oxindole

Creator:: Li, Yang
Abstract:: Irradiation of a tryptamine linked through its side-chain nitrogen to an alkylidene malonate residue results in an intramolecular [2 + 2] cycloaddition to the indole 2,3-double bond. The resultant cyclobutane undergoes spontaneous retro-Mannich fission to produce a spiro[indoline-3,3-pyrrolenine] with relative configuration defined by the orientation of substituents in the transient...
Resource Type:: Dissertation
Full Text:: .; Nicholson, A. A.; Tchir, M. F. Can. J. Chem. 1969, 47, 711. 8. (a) Kearns, D. R.; Marsh, G.; Schaffner, K

Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

Creator:: Zhu, Chenxi
Abstract:: Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
Resource Type:: Dissertation
Full Text:: the 30 years from 1981 to 2010. J Nat Prod, 2012. 75(3): p. 311-35. 9. Gould, K., Antibiotics

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Creator:: Kim, GilSoo
Abstract:: The first part of this manuscript is about the total synthesis of the aspidosperma alkaloids leuconoxine, melodinine E and mersicarpine. Our synthetic strategy used a radical translocation-conjugate addition cascade to construct the core of the natural product. Specifically, a vinyl radical was generated from the homolysis of the C–I bond...
Resource Type:: Dissertation
Full Text:: R.B Woodward, M.P. Cava, W.D. Ollis, A. Hunger, H.U. Daeniker, K. Schenker, J. Am. Chem. Soc. 1954

Part I: Synthetic Studies Toward Mandelalide A and Madeirolide A; Part II: Synthesis of Mandelalide/Madeirolide Hybrid Structures

Creator:: Li, Jinming
Abstract:: Mandelalide A has attracted considerable interest from the synthetic community due to its intriguing structure and important cytotoxic activity. Madeirolide A, a structurally related macrolide, shows promising antifungal activity but no appreciable anticancer activity. This dissertation describes synthetic studies toward mandelalide A, madeirolide A and their hybrid structures. Part I...
Resource Type:: Dissertation
Full Text:: . 1982, 104, 6846-6848. 6. Hale, K. J.; S. Manaviazar, S. Chem. Asian J. 2010, 5, 704-754. 7. Kollár

Polymeric submicron optical ion-selective sensors

Creator:: Bychkova, Valeriya
Abstract:: Ion-selective polymeric optical sensors – ion optodes – are a promising alternative to ion-selective electrodes and fluorescent dyes for analytical and biological applications, e.g. extra- and intracellular measurements. They are non-toxic, highly selective robust probes for ionic fluxes monitoring. A large-scale fabrication of ion optodes using a solvent displacement method...
Resource Type:: Dissertation
Full Text:: developed recently. They can reliably measure the most relevant cations (H + , Na + , K + , Ca 2+ , Mg

Expanding the scope of a Diels-Alder approach to biaryl synthesis

Creator:: Schwartz, Johanna Perkins
Abstract:: A Diels-Alder approach to biaryls (DAB) has been applied towards the synthesis of highly substituted, programmable biaryl templates. Tri- and tetra-ortho-substituted biaryls can be produced in just three to four steps from commercially available materials utilizing the Diels-Alder [4+2] cycloaddition. The methods described herein will illustrate the ability of mono...
Resource Type:: Dissertation
Full Text:: , S. A. J. Am. Chem. Soc. 2004, 126, 12888. (b) Nicolaou, K. C.; Hao, J.; Reddy, M. V

ScholarsArchive@OSU

Total Synthesis of Cephalotaxus Alkaloids and Synthetic Studies toward Bazzanin K

Part I: Synthetic Studies Towards Viridin, Halenaquinone, and Obtusanal. Part II: Analysis, Synthesis, and Characterization of Coronene Derivatives.

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Bioprospecting the Chemical Diversity of Plant-associated Fungi

Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to indole and oxindole

Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Part I: Synthetic Studies Toward Mandelalide A and Madeirolide A; Part II: Synthesis of Mandelalide/Madeirolide Hybrid Structures

Polymeric submicron optical ion-selective sensors

Expanding the scope of a Diels-Alder approach to biaryl synthesis

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