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Filtering by: Alternative title ssim EC 1579 Committee Member Blakemore, Paul R. License All rights reserved

Computational Investigation and Prediction of Mechanisms and Stereocontrol in Complex Organic Reactions

Creator:

Pattawong, Ommidala

Abstract:

Complex organic transformations, such as the addition of pyrrole to ketene using planar chiral organocatalyst (*PPY), the four-component anhydride- Manniach reactions, and the site-selective desymmetrization of meso-1,2-diol, are remarkable synthetic reactions that provide high yield and high selectivity. However, the exact mechanism and origins of stereocontrol for theses synthetic organic...

Resource Type:

Dissertation
Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Creator:

Shaw, Subrata

Abstract:

This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...

Resource Type:

Dissertation