Index Catalog // ScholarsArchive@OSU

Creator:: Pattawong, Ommidala
Abstract:: Complex organic transformations, such as the addition of pyrrole to ketene using planar chiral organocatalyst (*PPY), the four-component anhydride- Manniach reactions, and the site-selective desymmetrization of meso-1,2-diol, are remarkable synthetic reactions that provide high yield and high selectivity. However, the exact mechanism and origins of stereocontrol for theses synthetic organic...
Resource Type:: Dissertation
Full Text:: for in anhydride- Mannich reactions (AMR); and 4) the future catalyst design & expansion of the site

Creator:: Mahapatra, Subham
Abstract:: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Resource Type:: Dissertation
Full Text:: CO2Me H OTBS OTBS 3 steps Bu3Sn Mo(CO)3(NCtBu)3 Bu3SnH, THF 86%, 4:1 rr 1.44 1.50 1.48 1.46

Creator:: Shaw, Subrata
Abstract:: This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
Resource Type:: Dissertation
Full Text:: Thalidomide (1) (R)-antiemetic (S)-teratogenic MeO Ni,_ ( -.I) ' N CI H Nexium (4) racemic: Prilosec OH H

Creator:: Ashburn, Bradley O.
Abstract:: An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...
Resource Type:: Dissertation
Full Text:: provide increased potency. 4 EtO O NSAID - Antiarthritic (1.8) N CO2H O N N N H N

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