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Filtering by: Subject Antibiotics -- Synthesis Committee Member Blakemore, Paul R.

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:

Mahapatra, Subham

Abstract:

More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...

Resource Type:

Dissertation
Biosynthesis and modification of the antibiotic enduracidin

Creator:

Goebel, Neal C.

Abstract:

The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...

Resource Type:

Dissertation

Full Text:

, 2012. Title: Biosynthesis and Modification of the Antibiotic Enduracidin Abstract approved: T. Mark