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Filtering by: Committee Member Mcphail, Kerry Remove constraint Committee Member: Mcphail, Kerry Committee Member Blakemore, Paul R. Remove constraint Committee Member: Blakemore, Paul R.

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  • Strategies for the Synthesis of Nitrogeous Compounds : Aminal Radical Reaction and Pyridinium Oxide Cycloadditions

    Creator:
    Lu, Yi
    Abstract:
    Pharmaceuticals, molecular catalysts, and secondary metabolites often contain nitrogen. The problems faced synthesizing compounds which contain nitrogen was because of the Lewis base reactivity of nitrogen lone pairs, and the acidic protons of some nitrogenous functional groups. We developed two methods for the synthesis of nitrogeous compounds. Additionally, we successfully...
    Resource Type:
    Dissertation

  • Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

    Creator:
    Serrill, Jeffrey D.
    Abstract:
    Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
    Resource Type:
    Dissertation
    Full Text:
    academics. I would like to thank Dr. Kerry McPhail for acting as an active, supportive collaborator, and

  • Biosynthesis and modification of the antibiotic enduracidin

    Creator:
    Goebel, Neal C.
    Abstract:
    The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
    Resource Type:
    Dissertation
    Full Text:
    Mahmud. Phil Proteau and Kerry McPhail. It has been a privilege to have worked with you. The advice and

  • A Diels-Alder approach to biaryl synthesis

    Creator:
    Ashburn, Bradley O.
    Abstract:
    An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...
    Resource Type:
    Dissertation
    Full Text:
    . Paul R. Blakemore, Prof. Kerry L. McPhail, and Prof. William W. Warren for their guidance. I want to