Nutrigenomics is a branch of nutrition that seeks to elucidate the relationship between dietary components and expression of genes. Certain bioactive compounds present in the diet have the potential to modulate transcription of genes through their interactions with ligand-dependent nuclear receptors, a series of transcriptional regulators capable of sensing intracellular...
Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...