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Filtering by: Subject Surface chemistry Remove constraint Subject: Surface chemistry Committee Member Bothwell, Michelle Remove constraint Committee Member: Bothwell, Michelle Degree Field Chemical Engineering Remove constraint Degree Field: Chemical Engineering

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  • Molecular origins of surfactant-mediated stabilization of protein

    Creator:
    Lee, Hyo Jin
    Abstract:
    Nonionic surfactants are commonly used to stabilize proteins during upstream and downstream processing and drug formulation. Surfactants stabilize the proteins through two major mechanisms: (i) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (ii) their association with protein into "complexes" that prevent proteins from interacting...
    Resource Type:
    Dissertation
    Full Text:
    ]. 16 The extent of aggregation also depends upon the surface chemistry of the container in which