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Filtering by: Creator Spitz, Yvette H. Remove constraint Creator: Spitz, Yvette H. Committee Member Buermeyer, Andrew Remove constraint Committee Member: Buermeyer, Andrew Decade 2000-2009 Remove constraint Decade: 2000-2009

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  • A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

    Creator:
    Myzak, Melinda C.
    Abstract:
    Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
    Resource Type:
    Dissertation
    Full Text:
    approved: Roderick H. Dashwood Emily Targeting the epigenome, including the use of histone deacetylase

  • The role of zinc in the molecular and cellular events in the prostate

    Creator:
    Yan, Michelle
    Abstract:
    Zinc is an essential mineral that is integral to many proteins and transcription factors that regulate key cellular functions. The normal prostate accumulates high concentrations of zinc; however, malignant tissues have significantly lower zinc levels. This unique relationship between zinc and the prostate has sparked interest in the role of...
    Resource Type:
    Dissertation