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Filtering by: Subject Tetrachlorodibenzodioxin -- Toxicology Committee Member Buhler, Donald Decade 1990-1999

Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced modification of hepatic pyruvate carboxylase gene expression in C57BL/6J male mice

Creator:

Sparrow, Barney R.

Abstract:

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on hepatic pyruvate carboxylase (PC) gene expression were investigated in C57BL/6J Ah[superscipt b/b male mice. A dose-dependent reduction of PC levels and activity occurred in animals given a single intraperitoneal dose of TCDD in a corn oil carrier. The dose ranged from 1 to...

Resource Type:

Dissertation

Full Text:

OF THE THESIS OF Barney R. Sparrow for the degree of Doctor of Philosophy in Toxicology presented