Circadian clocks coordinate molecular, cellular, physiological, and behavioral processes with the 24-hour solar day. While clock functions are well understood in young animals, it is not clear how aging or neurodegenerative disease affects the various levels of the circadian system. A common symptom of many neurodegenerative diseases including Alzheimer’s disease...
Circadian clocks are endogenous molecular mechanisms that coordinate daily rhythms in gene expression, cellular activities, and physiological functions with external day/night cycles. Breakdown of circadian rhythms such as sleep/wake cycles is associated with the onset of several neurological diseases; however, it is not clear whether disruption of rhythms is a...
Interferon tau (IFN-τ) is the pregnancy recognition signal secreted by the trophectodermal cells of the developing bovine embryo that prevents luteolysis and maintains critical progesterone production. Recent evidence has suggested in addition to the mechanism of action identified in the uterus, there may be a direct effect of IFN-τ on...