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Filtering by: Creator Feindel, Kristin B. Committee Member Cooley, Richard Resource Type Honors College Thesis

Selection of an Orthogonal tRNA Synthetase for Trifluoromethyl-phenylalanine in Methanomethylophilus Alvus System

Creator:

Eyberg, Daniel R.

Abstract:

Genetic code expansion is a technology that allows for site-specific incorporation of noncanonical amino acids into recombinant proteins at amber stop codons using engineered translational machinery. The technology allows for expanded study into proteins, derived from the integration of novel chemical functions found in noncanonical amino acids, such as fluorescence,...

Resource Type:

Honors College Thesis

Full Text:

ncAA stringency in positive selection and barnase in the negative selection. B) General scheme for