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Filtering by: Creator Baker, Rick Remove constraint Creator: Baker, Rick Committee Member Cooley, Richard Remove constraint Committee Member: Cooley, Richard

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  • The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

    Creator:
    Jackson, Kendra K.
    Abstract:
    PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...
    Resource Type:
    Honors College Thesis
    Full Text:
    _____________________________________________________________________ Rick Cooley, Committee Member, representing Biochemistry and Biophysics

  • Revealing sequences and modifications of intact proteins using electron fragmentation

    Creator:
    Franklin, Rachel
    Abstract:
    People turn to mass spectrometry to answer some of life’s most important questions. From carbon dating of archeological finds to newborn blood screening tests, mass spectrometry allows us to measure molecules which helps advance our knowledge of life and the world we live in. One area of mass spectrometry that...
    Resource Type:
    Dissertation
    Full Text:
    collaborators at OSU, Rick Cooley and Phil Zhu, for their tremendous efforts in preparing the SR-linker

  • Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

    Creator:
    Estelle, Aidan B.
    Abstract:
    Interactions between proteins are essential to life, driving and regulating a majority of processes within all living cells. Study of protein-protein interactions reveals that some proteins act as hubs within networks of interactions, binding to many partner proteins. These hubs therefore are of particular importance to understanding protein function, interwoven...
    Resource Type:
    Dissertation
    Full Text:
    who so clearly didn’t know a thing. I also want to thank my committee. Rick, thank you for teaching

  • Strength in Numbers: How Multivalent WW-PPXY Interactions Regulate Cell Signaling

    Creator:
    Vogel, Amber J.
    Abstract:
    Cell signaling is often mediated by protein-protein interactions, which must be specific, tunable, and transient to allow agile responsiveness to cellular messages. Due to their unique properties, multivalent, intrinsically disordered proteins make ideal candidates to accomplish these vital tasks. A single protein with multiple binding sites may bind numerous partners,...
    Resource Type:
    Dissertation
    Full Text:
    , review manuscripts, and plan experiments when I needed extra help. Rick, I truly can’t count the number