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Filtering by: Committee Member Daley, Larry Creator Hall, Justin Daniel

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Creator:

Hall, Justin Daniel

Abstract:

Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...

Resource Type:

Dissertation