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Filtering by: Committee Member Dashwood, Rod Date issued sim 2005-12-14

Application of toxicogenomics to determine mechanism of tumor modulation by dietary indole phytochemicals in hepatocellular carcinoma

Creator:

Tilton, Susan C.

Abstract:

Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C derivative in vivo, are known chemopreventive agents available as dietary supplements. I3C was found to suppress or enhance tumors in several animal models. Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism effectively blocking initiation. However, mechanisms for enhancement...

Resource Type:

Dissertation