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Filtering by: Creator Mesecar, Roderick S. Committee Member Dashwood, Roderick H. Decade 2010-2019

The Response to Sulforaphane in Metastatic Prostate Cancer Cells

Creator:

Watson, Gregory

Abstract:

Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....

Resource Type:

Dissertation

Full Text:

Palomera- Sanchez, Chelsea Black, Claudia S Maier, David E Williams, Roderick H Dashwood and Emily Ho
The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:

Campbell, Yan

Abstract:

The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...

Resource Type:

Dissertation