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Gas-phase fragmentation chemistry of protonated peptide ions

Creator:

Bythell, Benjamin James

Abstract:

The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...

Resource Type:

Dissertation

Full Text:

2 AN ABSTRACT OF THE DISSERTATION OF Benjamin James Bythell for the degree of Doctor of
Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Creator:

Tonsiengsom, Sorasaree

Abstract:

Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...

Resource Type:

Dissertation

Full Text:

, SALACIN AND ALMAZOLES Abstract approved: Kevin P. Gable Studies
Structure elucidation of bioactive natural products from Madagascar marine algae and cyanobacteria

Creator:

Andrianasolo, Eric Hajaniriana

Abstract:

This thesis is an investigation of the natural products deriving from marine algae and cyanobacteria and has resulted in the discovery of eleven new secondary metabolites. The structure elucidations of these new molecules were performed using a variety of spectroscopic techniques. Four new macrolides were isolated and characterized from the...

Resource Type:

Dissertation