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Filtering by: Creator Olsen, Keith A. Remove constraint Creator: Olsen, Keith A. Committee Member Deinzer, Max Remove constraint Committee Member: Deinzer, Max File Format application/pdf Remove constraint File Format: application/pdf

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  • Structural studies of the antioxidant defense enzymes; copper, zinc superoxide dismutase and alkyl hydroperoxide reductase flavoprotein

    Creator:
    Roberts, Blaine R.
    Abstract:
    Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
    Resource Type:
    Dissertation
    Full Text:
    thiols of other thioredoxin family members. The N- terminal domain of AhpF provides a platform to

  • Development of fragmentation techniques in mass spectrometry for biological applications

    Creator:
    Ji, Hong
    Abstract:
    In this dissertation, I present the work of developing more efficient and economical techniques for fragmenting large bio-molecules, and ultimately making mass spectrometry a more powerful tool in proteomics, DNA sequencing, and other areas of biomolecular analysis. Aiming at lowering the installation and operating cost, and delivering electron capture dissociation...
    Resource Type:
    Dissertation
    Full Text:
    bio-molecules, and ultimately making mass spectrometry a more powerful tool in proteomics, DNA

  • Gas-phase fragmentation chemistry of protonated peptide ions

    Creator:
    Bythell, Benjamin James
    Abstract:
    The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...
    Resource Type:
    Dissertation
    Full Text:
    Protonated Peptide Ions by Benjamin James Bythell A DISSERTATION submitted to