Index Catalog // ScholarsArchive@OSU

Metabolic Effects in C57B/6J Mice Fed a High-Fat Diet Supplemented with Chromium Picolinate and Chromium Yeast

Creator:: Yu, Wesley
Abstract:: An estimated total of 30.3 million people have diabetes in the United States, a disease characterized by chronic elevation in blood glucose which over time, can lead to a host of health problems. Currently the most common types of diabetes are type 1, type 2, and gestational. The principal hormone...
Resource Type:: Honors College Thesis
Full Text:: Chromium A nutritionist-designed diet would typically contain 30𝜇g Cr/d (Anderson and Kozlovsky

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: (Bar Harbor, ME). Mice breeding was done at the Laboratory Animal Resources Center (LARC), Oregon

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Creator:: Sanchez, Karina M.
Abstract:: Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...
Resource Type:: Undergraduate Thesis
Full Text:: Clinical Research Center (CRC room 407) at the Linus Pauling Science Center (LSPC), Oregon State

Characterizing PM2.5 with Different Source Contributions

Creator:: Perez, Allison Mae S.
Abstract:: Ubiquitous fine particulate matter (PM2.5) exposures significantly impact global public health, yet little is known about the mechanisms causing these known adverse health effects. Oxidative stress due to PM2.5 associated chemical constituents, such as polycyclic aromatic hydrocarbons (PAHs), is a proposed possible mechanism for PM2.5 mediated health effects. Variations in...
Resource Type:: Honors College Thesis
Full Text:: -PAHs PAHs in pg PAH per µg PM2.5. C) Total concentration of nitro-PAHs in pg PAH per µg PM2.5. D

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Creator:: Raymundo, Wilfrido E.
Abstract:: Testing the many potential chemoprevention agents from dietary sources in animal or human models is expensive and takes a long time. In vitro models can be useful for screening the right compounds to use in larger studies. We tested the MatTek™ EpiIntestinal™ small intestine epithelial 3D cell culture model for...
Resource Type:: Undergraduate Thesis
Full Text:: BaP 80µM BaP 200µM 0 50 100 150 (% o f P BS /D C on tr ol ) ✱ *p = 0.0275 PBS/D 80 µM

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Creator:: Luo, Yun L.
Abstract:: Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
Resource Type:: Honors College Thesis
Full Text:: at the Oregon State University Center for Genome Research and Biocomputing (CGRB) with

Exploring Pactamycin Biosynthesis

Creator:: Roland, Jessica
Abstract:: Pactamycin, produced by the soil bacterium Streptomyces pactum, is a cytotoxic antibiotic that belongs to the aminocyclitol family of natural products. This antibiotic has shown various forms of biological activity, including antibacterial, antifungal, antimalarial, and antitumor activities. Despite its outstanding biological activity, the mode of formation of its pharmacophore (the...
Resource Type:: Honors College Thesis
Full Text:: . Pactamycin consists of a center aminocyclopentitol ring, 3-aminoacetophenone, 6- methylsalicylate (6-MSA

Preliminary Evidence that the Microbial Community may Produce Aliphatic Constituents and Induce Soil Water Repellency as a Response to Desiccation

Creator:: Chilcote, Emma T.
Abstract:: Soil water repellency is one cause of rill soil erosion and overland flow that results in the loss of fertile topsoil. Previous research suggests that since microbial growth depends on temperature/moisture and follows diurnal and seasonal cycles, a biological mechanism would be able to explain the observed seasonality and climate...
Resource Type:: Honors College Thesis
Full Text:: refuted. 1.8% 2% 3% -5 0 5 D iff er en ce in Q ua nt ity o f A lip ha tic C on st

Impact of lignin on efficiency of small-scale enzymatic hydrolysis of lignocellulosic biomass

Creator:: Potapchuk, Angelica
Abstract:: Energy production and consumption is a major environmental and economic concern in the world today. Biofuel produced from lignocellulosic biomass is being explored as an alternative energy source to petroleum. Lignocellulosic biomass is comprised of cellulose, hemicellulose, and lignin. To produce biofuels, lignocellulosic biomass must be broken down to expose...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: -25% lignin (Saha, 2005). Cellulose is a linear polymer consisting of D-glucose units joined by β

Analysis of boscalid resistance of isolates of Botrytis cinerea

Creator:: Villanueva, Brenda
Abstract:: Succinate dehydrogenase (Sdh) inhibitor fungicides, such as boscalid, are effective for the management of gray mold caused by the fungal pathogen Botrytis cinerea. Unfortunately, resistance to boscalid was common among isolates of the pathogen from small fruits grown in Oregon. Boscalid-resistance is commonly associated with mutations in Sdh, especially in...
Resource Type:: Undergraduate Thesis
Full Text:: University, Center for Genome Research and Biocomputing, Core Facilities, Corvallis, Oregon. Sequence

ScholarsArchive@OSU

Metabolic Effects in C57B/6J Mice Fed a High-Fat Diet Supplemented with Chromium Picolinate and Chromium Yeast

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Characterizing PM2.5 with Different Source Contributions

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Exploring Pactamycin Biosynthesis

Preliminary Evidence that the Microbial Community may Produce Aliphatic Constituents and Induce Soil Water Repellency as a Response to Desiccation

Impact of lignin on efficiency of small-scale enzymatic hydrolysis of lignocellulosic biomass

Analysis of boscalid resistance of isolates of Botrytis cinerea

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