Index Catalog // ScholarsArchive@OSU

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Creator:: Raymundo, Wilfrido E.
Abstract:: Testing the many potential chemoprevention agents from dietary sources in animal or human models is expensive and takes a long time. In vitro models can be useful for screening the right compounds to use in larger studies. We tested the MatTek™ EpiIntestinal™ small intestine epithelial 3D cell culture model for...
Resource Type:: Undergraduate Thesis
Full Text:: ., Planchais, J., Sokol, H. 2018. Gut microbiome regulation of tryptophan metabolism in health and disease

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Creator:: Luo, Yun L.
Abstract:: Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
Resource Type:: Honors College Thesis
Full Text:: ., Hawkins, G. A., Wiley, K. E., Bleecker, E. R., Walsh, P. C., Meyers, D. A., Isaacs, W. B., & Xu, J

Expression of prolactin in feline mammary adenomas and adenocarcinomas

Creator:: Trummel, Danielle K.
Abstract:: Mammary tumors are the third most common tumor in cats after cutaneous neoplasia and lymphosarcoma. More than 80% of feline mammary tumors are adenocarcinomas, which are similar to human mammary adenocarcinomas in their biologic behavior and histologic characteristics. Despite treatment with radical mastectomy, feline mammary adenocarcinoma is associated with a...
Resource Type:: Undergraduate Thesis and Presentation
Full Text:: . Basement Membrane Components in Mammary Tumours of the Dog and Cat. J Comp Pathol 109: 214-252, 1993. 2

Metabolic Effects in C57B/6J Mice Fed a High-Fat Diet Supplemented with Chromium Picolinate and Chromium Yeast

Creator:: Yu, Wesley
Abstract:: An estimated total of 30.3 million people have diabetes in the United States, a disease characterized by chronic elevation in blood glucose which over time, can lead to a host of health problems. Currently the most common types of diabetes are type 1, type 2, and gestational. The principal hormone...
Resource Type:: Honors College Thesis

Partial purification of endo-1,4-β-D-glucanase I of Trichoderma reesei and use in small-scale enzymatic hydrolysis of cellulose

Creator:: Pautsch, Lindsay
Abstract:: In order to reduce the cost of lignocellulosic ethanol production, a model was previously developed to predict the amount of fermentable sugar released based on parameters concerning both biomass and enzymes. To validate this model, enzymatic hydrolysis must be carried out using individual purified cellulase enzymes. Endo-1,4-β-D-glucanase I (EG I),...
Resource Type:: Undergraduate Thesis
Full Text:: ., Maximenko, V., Gilkes, N., Saddler, J., 2007. Optimization of enzyme complexes for lignocellulose

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Creator:: Sanchez, Karina M.
Abstract:: Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...
Resource Type:: Undergraduate Thesis
Full Text:: Pharmacol Exp Ther 187:185–194. 34. English PA, Williams JA, Martini J-F, Motzer RJ, Valota O, and Buller

Characterizing PM2.5 with Different Source Contributions

Creator:: Perez, Allison Mae S.
Abstract:: Ubiquitous fine particulate matter (PM2.5) exposures significantly impact global public health, yet little is known about the mechanisms causing these known adverse health effects. Oxidative stress due to PM2.5 associated chemical constituents, such as polycyclic aromatic hydrocarbons (PAHs), is a proposed possible mechanism for PM2.5 mediated health effects. Variations in...
Resource Type:: Honors College Thesis

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: ) dams on a mouse Cyp1b1 (mCyp1b1) null background were a gift from Frank J. Gonzalez of the National

Exploring Pactamycin Biosynthesis

Creator:: Roland, Jessica
Abstract:: Pactamycin, produced by the soil bacterium Streptomyces pactum, is a cytotoxic antibiotic that belongs to the aminocyclitol family of natural products. This antibiotic has shown various forms of biological activity, including antibacterial, antifungal, antimalarial, and antitumor activities. Despite its outstanding biological activity, the mode of formation of its pharmacophore (the...
Resource Type:: Honors College Thesis
Full Text:: -Warren, R. J.; Wimberly, B. T.; Ramakrishnan, V. Cell 2000, 103(7), 1143. 5. Lu, W.; Roongsawang, N

Analysis of boscalid resistance of isolates of Botrytis cinerea

Creator:: Villanueva, Brenda
Abstract:: Succinate dehydrogenase (Sdh) inhibitor fungicides, such as boscalid, are effective for the management of gray mold caused by the fungal pathogen Botrytis cinerea. Unfortunately, resistance to boscalid was common among isolates of the pathogen from small fruits grown in Oregon. Boscalid-resistance is commonly associated with mutations in Sdh, especially in...
Resource Type:: Undergraduate Thesis
Full Text:: . Accessed 5 August 2019. Cenis, J. (1992). Rapid extraction of fungal DNA for PCR amplification

ScholarsArchive@OSU

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Expression of prolactin in feline mammary adenomas and adenocarcinomas

Metabolic Effects in C57B/6J Mice Fed a High-Fat Diet Supplemented with Chromium Picolinate and Chromium Yeast

Partial purification of endo-1,4-β-D-glucanase I of Trichoderma reesei and use in small-scale enzymatic hydrolysis of cellulose

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Characterizing PM2.5 with Different Source Contributions

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Exploring Pactamycin Biosynthesis

Analysis of boscalid resistance of isolates of Botrytis cinerea

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