Index Catalog // ScholarsArchive@OSU

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: Environmental and Molecular Toxicology/Linus Pauling Institute William M. Baird, Committee Member

Expression of prolactin in feline mammary adenomas and adenocarcinomas

Creator:: Trummel, Danielle K.
Abstract:: Mammary tumors are the third most common tumor in cats after cutaneous neoplasia and lymphosarcoma. More than 80% of feline mammary tumors are adenocarcinomas, which are similar to human mammary adenocarcinomas in their biologic behavior and histologic characteristics. Despite treatment with radical mastectomy, feline mammary adenocarcinoma is associated with a...
Resource Type:: Undergraduate Thesis and Presentation
Full Text:: and 37 Expression of Prolactin in Feline Mammary Adenomas and Adenocarcinomas By Danielle K

Impact of lignin on efficiency of small-scale enzymatic hydrolysis of lignocellulosic biomass

Creator:: Potapchuk, Angelica
Abstract:: Energy production and consumption is a major environmental and economic concern in the world today. Biofuel produced from lignocellulosic biomass is being explored as an alternative energy source to petroleum. Lignocellulosic biomass is comprised of cellulose, hemicellulose, and lignin. To produce biofuels, lignocellulosic biomass must be broken down to expose...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: Bioengineering. 2008;101(5):913-925. doi:10.1002/bit.21959. 2. Trajano HL, Engle NL, Foston M, Ragauskas AJ

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Creator:: Sanchez, Karina M.
Abstract:: Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...
Resource Type:: Undergraduate Thesis
Full Text:: column (4.6 mm × 150 mm, 100 Å, 5 μm; GL Sciences, Torrance, CA, USA) eluted with solvent A (water with

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Creator:: Luo, Yun L.
Abstract:: Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
Resource Type:: Honors College Thesis
Full Text:: :5105-11. Alexandrov K, Cascorbi I, Rojas M, Bouvier G, Kriek E, Bartsch H. 2002. CYP1A1 and GSTM1

Metabolic Effects in C57B/6J Mice Fed a High-Fat Diet Supplemented with Chromium Picolinate and Chromium Yeast

Creator:: Yu, Wesley
Abstract:: An estimated total of 30.3 million people have diabetes in the United States, a disease characterized by chronic elevation in blood glucose which over time, can lead to a host of health problems. Currently the most common types of diabetes are type 1, type 2, and gestational. The principal hormone...
Resource Type:: Honors College Thesis

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Creator:: Raymundo, Wilfrido E.
Abstract:: Testing the many potential chemoprevention agents from dietary sources in animal or human models is expensive and takes a long time. In vitro models can be useful for screening the right compounds to use in larger studies. We tested the MatTek™ EpiIntestinal™ small intestine epithelial 3D cell culture model for...
Resource Type:: Undergraduate Thesis
Full Text:: , K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., Yin, Y. 2018. Impact of the gut microbiota on

Partial purification of endo-1,4-β-D-glucanase I of Trichoderma reesei and use in small-scale enzymatic hydrolysis of cellulose

Creator:: Pautsch, Lindsay
Abstract:: In order to reduce the cost of lignocellulosic ethanol production, a model was previously developed to predict the amount of fermentable sugar released based on parameters concerning both biomass and enzymes. To validate this model, enzymatic hydrolysis must be carried out using individual purified cellulase enzymes. Endo-1,4-β-D-glucanase I (EG I),...
Resource Type:: Undergraduate Thesis
Full Text:: (Bio-Rad, USA) which measured conductivity and ultraviolet light absorbance at 280 ηm. All

Characterizing PM2.5 with Different Source Contributions

Creator:: Perez, Allison Mae S.
Abstract:: Ubiquitous fine particulate matter (PM2.5) exposures significantly impact global public health, yet little is known about the mechanisms causing these known adverse health effects. Oxidative stress due to PM2.5 associated chemical constituents, such as polycyclic aromatic hydrocarbons (PAHs), is a proposed possible mechanism for PM2.5 mediated health effects. Variations in...
Resource Type:: Honors College Thesis
Full Text:: was added to 100 l 0.05 M phosphate buffered saline (PBS) and 5 l DTT. DTT was analyzed at 6

Preliminary Evidence that the Microbial Community may Produce Aliphatic Constituents and Induce Soil Water Repellency as a Response to Desiccation

Creator:: Chilcote, Emma T.
Abstract:: Soil water repellency is one cause of rill soil erosion and overland flow that results in the loss of fertile topsoil. Previous research suggests that since microbial growth depends on temperature/moisture and follows diurnal and seasonal cycles, a biological mechanism would be able to explain the observed seasonality and climate...
Resource Type:: Honors College Thesis
Full Text:: 2 3 4 5 6 M oi st ur e C on te nt (% ) Hours after Initial Wetting 0 24 48 72 96 1 2

ScholarsArchive@OSU

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Expression of prolactin in feline mammary adenomas and adenocarcinomas

Impact of lignin on efficiency of small-scale enzymatic hydrolysis of lignocellulosic biomass

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Metabolic Effects in C57B/6J Mice Fed a High-Fat Diet Supplemented with Chromium Picolinate and Chromium Yeast

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Partial purification of endo-1,4-β-D-glucanase I of Trichoderma reesei and use in small-scale enzymatic hydrolysis of cellulose

Characterizing PM2.5 with Different Source Contributions

Preliminary Evidence that the Microbial Community may Produce Aliphatic Constituents and Induce Soil Water Repellency as a Response to Desiccation

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