Index Catalog // ScholarsArchive@OSU

Utilization of structure-activity-relationship for predicting chemical toxicity in primary human lung cells

Creator:: Galbreath, Amanda
Abstract:: There is a growing need to establish alternative approaches for assessing hazard from chemical exposure compared to the traditional method of animal testing. Approaches that relate chemical structure to biological activity are gaining acceptance in the field as in silico methods for characterizing and predicting chemical toxicity. In this study,...
Resource Type:: Undergraduate Thesis

Development of a diagnostic assay for Phytophthora ramorum lineage detection

Creator:: Roig-Paul, Mireia
Abstract:: Phytophthora ramorum is the causal agent of Sudden Oak Death (SOD), which is an economically and environmentally important disease causing up to 80% mortality of tanoaks in Pacific Northwest coastal forests (LeBoldus et al., 2022). There are currently four clonal lineages in the United States and Europe, named North America...
Resource Type:: Undergraduate Thesis

Anti-Mullerian Hormone (AMH) Levels Are Reduced by Age, But Do Not Correlate With Pregnancy In Timed-Mated Rhesus Monkey Females (Macaca mulatta)

Creator:: Roth, Maggie
Abstract:: Infertility is an issue affecting millions of women across the globe, yet the causes are not fully understood, and treatment options are often ineffective. The evaluation of reproductive hormones has been a common tool used by fertility clinics as a way to predict the ovarian response to treatment and gain...
Resource Type:: Undergraduate Thesis

Light quality manipulation for the solvent extraction of phycocyanin from Oregon freshwater cyanobacteria

Creator:: Gregor, Katelin
Abstract:: Phycocyanin, a photosynthetic pigment-protein complex produced by cyanobacteria, has critical value in the medical field at high purity. Costs associated with the extraction of this pigment are high, emphasizing the importance of optimal growth conditions. The aim of this study was to investigate potential commercial producers of phycocyanin by evaluating...
Resource Type:: Honors College Thesis

Monitoring Resistance in Onion Thrips to Insecticides, Lannate® and Exirel®, in the Treasure Valley of Eastern Oregon and Southwestern Idaho

Creator:: Sanchez, Kevin
Abstract:: To evaluate and monitor insecticide resistance in onion thrips Thrips tabaci on onion (Allium cepa), we conducted a study using three field populations in the Treasure Valley of eastern Oregon and southwestern Idaho using the insecticides Lannate (methomyl) and Exirel (cyantraniliprole). To evaluate these two insecticides, biological assays were conducted...
Resource Type:: Undergraduate Thesis

VOC Emisions and Categorization in Axenic Growth Conditions by Phaeodactylum tricornutum

Creator:: Thompson, Douglas A.
Abstract:: Volatile organic compounds (VOCs) play an integral role in climate change and as a carbon source for organisms living in a marine environment. These compounds have many sources, but the impacts of biogenically produced VOCs is not fully known. Phaeodactylum tricornutum was studied under axenic ideal growth conditions to determine...
Resource Type:: Undergraduate Thesis

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Creator:: Valdez, Teresa
Abstract:: There is increased emphasis on understanding cumulative risk from the combined effects of chemical and non-chemical stressors as it relates to public health. Recent animal studies have identified pulmonary inflammation as a possible modifier and risk factor for chemical toxicity in the lung after exposure to inhaled pollutants; however, little...
Resource Type:: Honors College Thesis

Changes in Otolith Shape in Juvenile Chinook Salmon in Different Hatchery Rearing Conditions

Creator:: Ehrke, Melissa A.
Abstract:: The decline of the Chinook Salmon has been a mystery of recent years due to their decline. It has been speculated that wild origin salmon have more vigor and survivability than hatchery reared fish. This is thought to be due to rearing conditions, possibly affecting sensory organ development. The sensory...
Resource Type:: Undergraduate Thesis

A Performance Evaluation of In-Stream Hatchboxes and Streamside Incubators for Chinook Salmon

Creator:: Howell, Meghan Z.
Abstract:: Hatcheries are used to produce salmon to augment the number of fish available for harvest, and to supplement wild populations that may be threatened with extinction. Although traditional hatchery rearing methods can produce many fish, they can pose risk to wild populations because they tend to produce salmon with lower...
Resource Type:: Undergraduate Thesis

Guinea pig model of mild hyperandrogenemia – is it a suitable model for women with polycystic ovary syndrome (PCOS)? A pilot study

Creator:: Barboza Sagrero, Juriana E.
Abstract:: Polycystic Ovary Syndrome (PCOS) is an idiopathic disorder prevalent in ~5-10% of reproductive-aged women. In PCOS women who become pregnant, many experience complications including increased susceptibility of having a miscarriage, high blood pressure, and gestational diabetes, among others. Additionally, exposure to PCOS may have transgenerational impacts: offspring may be at...
Resource Type:: Undergraduate Thesis

A Comparative Analysis of Mercury and Lead in Sindoor from the U.S. and Bangladesh

Creator:: Breen, Anna K.
Abstract:: Heavy metals have historically been popular for use in cosmetics manufacturing due to the colorful pigmentation of heavy metal compounds. In the case of sindoor, a cosmetic used by married Hindu women for religious purposes, mercury sulfide, lead tetroxide, and lead chromate are compounds suspected to still be involved in...
Resource Type:: Honors College Thesis

A Performance Evaluation of In-Stream Hatchboxes and Streamside Incubators for Chinook Salmon

Creator:: Howell, Meghan Z.
Abstract:: Hatcheries are used to produce salmon to augment the number of fish available for harvest, and to supplement wild populations that may be threatened with extinction. Although traditional hatchery rearing methods can produce many fish, they can pose risk to wild populations because they tend to produce salmon with lower...
Resource Type:: Presentation

Overview of the Comparison of Commercial Pelagic Species Fisheries Management in Malaysia and Oregon, United States

Creator:: Ahmad, Amir
Abstract:: The United Nations Food and Agriculture Organization (FAO) in the State of World Fisheries and Aquaculture 2018, has observed that the trend of the world’s marine fish stocks has been overexploited, depleted, and has exhibited decreasing trend within the fraction of biologically sustainable levels. While these situations are an alarming...
Resource Type:: Undergraduate Thesis

Stomach Analysis of Top Aquatic Predators in a Headwater Stream Network

Creator:: Ain, Najma
Abstract:: Top predators play important roles in regulating communities and ecosystem processes in freshwater ecosystems. In the headwater stream network, it is crucial to understand the interspecific interaction between multiple predators. In Oregon forested ecosystems, Coastal Giant Salamander (Dicamptodon tenebrosus) and cutthroat trout (Oncorhynchus clarkii) are the top predators in many...
Resource Type:: Undergraduate Thesis

Tumorigenic bacteria from blueberry stem galls are related to Rhizobium tumorigenes-like Agrobacteria found in Rhododendron crown gall in Germany

Creator:: Khalib, Nurul Ain
Abstract:: Blueberry stem galls in Pacific Northwest are often attributed to Agrobacterium tumefaciens. The disease also is associated with indole-3-acetic-acid (IAA) producing bacteria, as described on cranberry stem gall. Lack of studies makes it difficult to conclude whether these two types of bacteria could be the causal agent of stem gall...
Resource Type:: Undergraduate Thesis

Use of Platelet Rich Plasma for the Treatment of Subclinical Endometritis in Beef Heifers

Creator:: Puttman, Elizabeth A.
Abstract:: Postpartum uterine inflammation (endometritis) is not uncommon in beef cattle, resulting in infertility and culling. Prolonged calving may contribute to the increased incidence of endometritis in heifers. Commonly used methods to treat endometritis in beef cattle include intrauterine antibiotics and/or hormone injections, which can result in meat residues. Platelet rich...
Resource Type:: Presentation and Undergraduate Thesis

An Evaluation of Staffing Needs at the Health Clinic in Maunatlala, Botswana

Creator:: Bedge, Sonya S.
Abstract:: As part of the Botswana Global Learning Internship Program, a qualitative study was conducted regarding the current staffing conditions at the local village health clinic in Maunatlala, Botswana. This was a month-long project conducted over the summer of 2018. Students from Oregon State University lived in the village of Maunatlala...
Resource Type:: Honors College Thesis

Vegetative effects of RNAi-suppression of the poplar homolog of LEAFY in the field

Creator:: Jacobson, Jeremy
Abstract:: Due to public and regulatory restrictions, genetic containment technology is critical for research and development of transgenic trees in forestry. A multi-year field trial demonstrated that the RNAi-LFY construct successfully induces sexual sterility in 6K10 poplar (Populus alba) without visible effects on vegetative development. However, its limited number of replicates...
Resource Type:: Undergraduate Thesis and Presentation

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Creator:: Mans, Michael-Andres D.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Resource Type:: Undergraduate Thesis

Insights into the Host Range, Population Decline, and Pathogenicity to Potato of Globodera ellingtonae

Creator:: Baker, Hannah V.
Abstract:: This thesis project has the following specific objectives: (i) Determine pathogenicity of Globodera ellingtonae to potato utilizing two trials conducted over a 16 week period, (ii) Elucidate the host range of G. ellingtonae using a variety of different Solanum weed species and crop species, and (iii) Characterize population decline of...
Resource Type:: Honors College Thesis

De novo Discovery of Novel Long Noncoding RNAs in the North American Beaver

Creator:: Kashyap, Amita
Abstract:: Long noncoding RNAs (lncRNAs) are RNA molecules that are at least 200 nucleotides long and do not encode proteins. lncRNAs have roles in gene regulation, chromatin epigenetics, and molecular scaffolding. In light of mounting evidence implicating species-specific noncoding RNAs and gene regulatory mechanisms in species adaptations, it is reasonable to...
Resource Type:: Honors College Thesis

Discovery and Characterization of New Cyanobacterial Natural Products from Moorea sp

Creator:: Cowley, Elise Shylo
Abstract:: Natural products (secondary metabolites) are small organic molecules derived from plants, microbes, and marine organisms that have served as a diverse source of useful compounds pharmaceuticals. New biologically active natural products are critical as anti-infective and cancer drug leads. Cyanobacteria, or blue-green algae, produce diverse cytotoxic metabolites that represent potential...
Resource Type:: Honors College Thesis

The Release of Nickel from Stainless Steel into Cooked Foods

Creator:: Kamerud, Kristin L.
Abstract:: Toxicological studies show that oral doses of nickel can cause allergic contact dermatitis, and routes of exposure, such as nickel leached from stainless steel cookware are not well characterized. In this study, four variables: grade of stainless steel, cook time, stainless steel seasoning or cooking cycles, and commercial tomato sauces,...
Resource Type:: Undergraduate Thesis and Presentation

Probing Circadian Clock-Steroid Receptor Interactions in GnRH Neurons

Creator:: Grimwood, Victoria J.
Abstract:: Endogenous circadian clock regulation is essential to normal rhythmicity, particularly the timing of hormone release in the brain. In the context of mammalian reproduction, a surge of a specific hormone, gonadotrophin-releasing hormone (GnRH), initiates a surge of luteinizing hormone (LH) from the pituitary gland, which is required for ovulation in...
Resource Type:: Honors College Thesis

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:: Kernan, Casey P.
Abstract:: DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Resource Type:: Presentation and Undergraduate Thesis

Discovery and Isolation of Bioactive Natural Products from Actinomycete Bacteria with an Examination ofInfectious Disease Drug Development and Application : A Comparison of the Developing and Developed Worlds

Creator:: Petrossian, Gregory
Abstract:: New antibiotic compounds with novel mechanisms of action have become essential in response to the recent paradigm of increasingly resistant strains of bacteria. Secondary metabolites (natural products) from bacteria such as Actinobacteria serve as lead compounds for the development of pharmaceutical drugs widely used to fight bacterial, viral and fungal...
Resource Type:: Research Paper

Automated annotation of Caenorhabditis mitochondrial genomes and phylogenetic analysis

Creator:: Campbell, Jessica L.
Abstract:: Motivation Relatively little is known about the evolution of mitochondrial genomes between Caenorhabditis species despite decades of research. Both the worldwide search for new nematode species and the effort to increase sequencing speeds require automated tools to quickly characterize and categorize large amounts of data. Results We developed an automated...
Resource Type:: Presentation and Undergraduate Thesis

Inhibition of α-Amylase and α-Glucosidase by Bioflavonoids

Creator:: Griffith, Anneke M. (Tucker)
Abstract:: Various flavonoid-rich plant extracts have shown efficacy in the treatment of diabetes. Although it is often assumed that dietary flavonoids exert biological antioxidant effects, it is possible that the observed effects work in carbohydrate metabolism. In this study we evaluated the effect of catechins and catechin containing extracts on α-amylase...
Resource Type:: Presentation and Honors College Thesis

Enzyme-Mediated Conversion of Glucolimnanthin to Bioherbicidal Breakdown Products

Creator:: Bratton, Daniel
Abstract:: The oilseed crop Limnanthes alba (white meadowfoam) is grown in Oregon. Methods were developed for the production of a liquid-based bioherbicide from meadowfoam seed meal (MSM). It was determined that glucosinolate-containing extracts of MSM can be combined with active-enzyme-containing liquid extracts of meadowfoam seed to form a fermented product rich...
Resource Type:: Undergraduate Thesis

Quantification of Cytokine Production Following Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Determine Potential Role in Suppression of the Immune Response in a Graft versus Host (GvH) Model

Creator:: Magaña, Laura Cristal
Abstract:: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant and a prototypic ligand for the aryl hydrocarbon receptor (AhR). In a graft versus host (GvH) response, treatment with TCDD suppresses a cytotoxic T-lymphocyte (CTL) response by Day 10, concurrent with a T-regulatory (Treg) like phenotype in the donor CD4+ T-cells, observed on Day...
Resource Type:: Undergraduate Thesis and Presentation

Response of reef fish assemblages to overgrowth of the hydrocoral Millepora complanata by the crustose alga Ramicrusta sp.

Creator:: Adams, AnnaRose
Abstract:: Natural disturbances and human activities can alter the benthic composition of coral reefs and other marine ecosystems. Reef fishes that associate with particular structures on the sea floor, such as coral heads, may be vulnerable to perturbations of those habitats. The spread of a newly discovered crustose alga (Ramicrusta sp.)...
Resource Type:: Honors College Thesis

Pheromone mating disruption of filbertworm moth (Cydia latiferreana)in commercial hazelnut orchards

Creator:: Hedstrom, Christopher
Abstract:: BACKGROUND: Oregon produces 99% of the hazelnuts grown in the United States. The key pest threatening commercial hazelnut orchards in Oregon is Cydia latiferreana (Tortricidae), filbertworm moth (FBW). Currently, most growers control FBW with one to two applications of esfenvalerate (Asana XL), a broad spectrum pyrethroid. Pheromone mating disruption is...
Resource Type:: Undergraduate Thesis and Presentation

Identification of bacteria crucial to histamine formation and monitoring their occurrence and histamine accumulation in scombroid fish

Creator:: Kim, Shin-Hee
Abstract:: Bacterial histamine formation in mackerel and albacore was studied by inducing histamine in the muscles under controlled storage conditions. The optimum temperature for histamine formation was 25°C. The highest level of histamine detected was 283 mg/100 g in the 2-day stored mackerel; and 67.1 mg/100 g in the 6-day stored...
Resource Type:: Dissertation

Coarse woody detritus dynamics, variable decay rates and their contribution to wildland fuel succession following high-severity fire disturbance in dry-mixed conifer forests of Oregon's eastern Cascades

Creator:: Dunn, Christopher J.
Abstract:: Reducing future fire severity is a proposed ecological benefit of salvage logging following wildfire disturbance. Considerable debate continues over the ability of such management practices to achieve this objective given limited understanding of coarse woody detritus (CWD) dynamics, fuel bed alterations, and post-fire vegetative growth. The objective of this study...
Resource Type:: Masters Thesis

Investigation of microbial extracts as a source of neurological agents

Creator:: Malmo, Jay M.
Abstract:: This study tested natural products from cyanobacteria from the Red Sea in Egypt and marine tunicates from the Algoa Bay in South Africa. Products from marine organisms have been used as lead compounds for the synthesis of new drugs because of their biological activity mechanism. Specifically, these products may contain...
Resource Type:: Research Paper

Developing Trap and Kill Technologies to Improve Management of the Western Spotted Cucumber Beetle (Diabrotica undecimpunctata undecimpunctata) and the Western Striped Cucumber Beetle (Acalymma trivittatum)

Creator:: Alderman, Katie
Abstract:: The western spotted cucumber beetle (Diabrotica undecimpunctata undecimpunctata) and the western striped cucumber beetle (Acalymma trivittatum) are pests of many crops, including vegetable, fruit, and nursery crops. Pesticides are commonly used to control this pest. Trap and kill technologies are under development as use in an alternative control for cucumber...
Resource Type:: Undergraduate Thesis and Presentation

Survey of rhizosphere associated entomopathogenic fungi on small fruits and Christmas trees in the Willamette Valley, OR

Creator:: Fisher, Joanna J.
Abstract:: The entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana are commercially available as microbial control agents for the black vine weevil, Otiorhynchus sulcatus (F.) (Coleoptera: Curculionidae), the key root-feeding insect pest in Pacific Northwest small fruits and ornamentals. Understanding habitat selection is critical to improve the efficacy, persistence and cost of...
Resource Type:: Honors College Thesis

Zooplankton of the Galapagos Islands

Creator:: Figueroa, Diego
Abstract:: The marine climate of the Galapagos is spatially and seasonally heterogeneous. A taxonomically comprehensive study of Galapagos zooplankton has never been done. This study is an initial effort to establish the distribution and community structure of zooplankton in the Archipelago. I collected zooplankton samples by vertical tows over the Galapagos...
Resource Type:: Dissertation

Development of a colorimetric test kit to determine enzymatically produced pyruvic acid in sweet onions

Creator:: Merrill, Dawn C.
Abstract:: Sweet onions are valued for their unique flavor and praised for their health and dietary character. Onion sweetness is perceived as the degree of pungency decreases. Pungency can be quantitatively determined in onions by measuring enzymatically produced pyruvic acid. The onion industry quantifies a sweet onion as one having a...
Resource Type:: Undergraduate Thesis and Presentation

Effects of Perfluorinated Compounds on GnRH Gene Expression in vitro

Creator:: Bathke, Rebecca E.
Abstract:: Perfluorinated chemicals have been widely used in industry for their superior surfactant qualities. Because of their widespread usage and resistance to photolytic and biodegradation mechanisms, as well as their ability to undergo long-range atmospheric transport, these compounds have become ubiquitous in the world-wide water supplies. Of particular interest are perfluorooctanoic...
Resource Type:: Undergraduate Thesis and Presentation

Immunohistochemistry Studies of Tumor Necrosis Factor Αlpha and Interferon Gamma Expression in Pseudocapillaria tomentosa Infected and Uninfected Zebrafish

Creator:: Lo, Lalee C.
Abstract:: Tumor necrosis factor alpha (TNF α) and interferon gamma (IFN γ) were initially recognized as inflammatory mediators produced by immune cells in response to infectious agents or foreign material. (1,5) However, over the past decade much research in mammalian species has indicated that these proteins also play key roles in...
Resource Type:: Presentation and Undergraduate Thesis

Integration of embryonic zebrafish and passive sampling device extracts to explore effects of pesticide mixtures

Creator:: Corvi, Margaret
Abstract:: Pesticides are ubiquitous, with more than one billion tons of pesticide products used in the United States annually. These compounds are characterized by their toxic effects to the target organism; however, pesticides are also well known for their deleterious effects to non-target species. Because pesticides have ecological and human health...
Resource Type:: Undergraduate Thesis and Presentation

Superior Anti-tumor Activity Exhibited From a Gemcitabine Prodrug Incorporated into Lecithin-Based Nanoparticles

Creator:: Sandoval, Michael
Abstract:: Cancer is class of diseases that has great diversity and unfortunately is one of the leading causes of death in the United States. Chemotherapy remains an important cancer treatment modality, and superior chemotherapeutic drugs are constantly being sought. Gemcitabine is an anti-tumor chemotherapeutic drug and it is the first line...
Resource Type:: Poster, Undergraduate Thesis, and Presentation

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