The objective of the present research was to determine, by use of the progesterone receptor antagonist RU-486, whether progesterone by autocrine/paracrine action suppresses phosphatidylinositol hydrolysis, and thus, the production of prostaglandin F2a during the midluteal phase of the estrous cycle in ewes. Two experiments were performed. Experiment 1 consisted of...
Cells of the ventrolateral dermomyotome delaminate and migrate into the limb buds where they give rise to all muscles of the limbs. The migratory cells proliferate and form myoblasts, which withdraw from the cell cycle to become terminally differentiated myocytes. The regulatory mechanisms that control the later steps of this...