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Filtering by: Subject Iron -- Absorption and adsorption Committee Member Forbes, Leonard Degree Name Master of Science (M.S.)

The adsorption of human recombinant factor VIII in the presence of the nonionic triblock surfactant Pluronic® F-68 at the air-water interface

Creator:

Alkhatib, Aveen K.

Abstract:

The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the presence of the nonionic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock surfactant Pluronic® F-68 was evaluated by dynamic air-water tensiometry. Surface tension kinetics were recorded for F-68 in the absence of protein at concentrations ranging from 0 to 10,000...

Resource Type:

Masters Thesis

Full Text:

the biopharmaceutical industry to stabilize therapeutic proteins from aggregation and adsorption
Surfactant interactions with recombinant factor VIII at the air/water interface

Creator:

Chu, Liping

Abstract:

The surface tension kin'ti4tnd ste'dy state behavior exhibited by mixtures of selected surfactants with a recombinant Factor VIII (rFVIII) were evaluated with automated interfacial tensiometry. In particular, fresh solutions of rFVIII with different concentrations of Tween 80, sodium dodecylsulfate (SDS), or dodecyltrimethylammonium bromide (DTAB) were prepared and their surface tension...

Resource Type:

Masters Thesis

Full Text:

adsorption and subsequent rearrangement (including protein-surfactant dissociation) at the interface. The