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  • Transcriptional networks controlled by the fatty acid regulators FAR-1 and FAR-2

    Creator:
    Bredeweg, Erin L.
    Abstract:
    Fungi are capable of growth on a wide variety of carbon sources, both living and dead. They can produce an arsenal of enzymes and transporters for harvesting sugars, polysaccharides, amino acids, lipids and micronutrients from their environments [1]. Within the nucleus of a cell, transcription factors (TF) control whether genes...
    Resource Type:
    Dissertation
    Full Text:
    !FARN1,!or!Fatty!Acid!Regulator!N1! (NCU08000)!to!light!regulation,!but!has!continued!toward

  • Cellular events conditioned by the Np gene of Pisum sativum L. in response to reduced UV light, weevil oviposition, and bruchins

    Creator:
    Ketter, Ann P.
    Abstract:
    In Pisum, the Np gene conditions two mitotic responses - to bruchid weevil oviposition on the pod and to reduced UV light. Oviposition by the weevil results in tumorous or neoplastic growth under the egg. Biochemically active compounds, called bruchins, were isolated from two bruchid insects (Doss et al, 2000)....
    Resource Type:
    Masters Thesis
    Full Text:
    and characterized (Fig. 3). The first identified was a monoester of 3-hydroxypropanoic acid and a

  • The Analysis of Hormone-dependent Transcription Factors and lncRNAs in Seeds by RNA Sequencing

    Creator:
    Sall, Khadidiatou
    Abstract:
    Seed dormancy is defined as the inability of viable seeds to germinate under conditionsotherwise favorable for germination. Dormancy provides a strategy for seeds to germinateat an appropriate time. Abscisic acid (ABA) is a major hormone involved in the regulationof seed dormancy. To elucidate the molecular mechanisms of dormancy, the twoexperimental...
    Resource Type:
    Dissertation
    Full Text:
    homology in amino acid sequence to DOG1, a major regulator of seed dormancy. Induction of DOGL4 alone in

  • Transcriptional regulation of mouse epidermal permeability barrier development and homeostasis by Ctip2

    Creator:
    Wang, Zhixing
    Abstract:
    Skin is the largest organ in the body that protects the organism from environmental, chemical and physical traumas of each passing day. The protective skin epidermal permeability barrier (EPB) is formed within the exterior layers of the epidermis, which are regularly sloughed off and repopulated by movement of inner cells....
    Resource Type:
    Dissertation
    Full Text:
    and marked increase in fatty acid synthesis by upregulating the activity and mRNA levels of several

  • Mechanisms for the interaction of environmental mycobacteria with host cells

    Creator:
    Harriff, Melanie J.
    Abstract:
    Environmental mycobacteria are important opportunistic pathogens for many hosts, including humans, cattle, and fish. Two well-studied species are Mycobacterium avium subsp. avium, a significant cause of disseminated bacterial disease in patients with AIDS, and Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s disease in cattle. Many other species that are...
    Resource Type:
    Dissertation
    Full Text:
    invasion. A mycobacterial protein (CipA) with an amino acid sequence suggestive of an ability to be a

  • In vitro and in vivo approaches for the functional characterization of the scaffold protein, GRASP

    Creator:
    Venkataraman, Anand
    Abstract:
    Studies using the pluripotent embryonic carcinoma cell line, P19, as a retinoic acid (RA)-responsive model system have been instrumental towards our understanding of the RA-dependent signaling pathways in development and homeostasis. Grp1-associated scaffold protein (GRASP; also known as Tamalin) was first identified by our group, as a gene robustly induced...
    Resource Type:
    Dissertation
    Full Text:
    retinoic acid (RA)-responsive model system have been instrumental towards our understanding of the RA

  • Calpain 2 proteolysis regulates glioblastoma cell invasion

    Creator:
    Lal, Sangeet Kumar
    Abstract:
    Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
    Resource Type:
    Dissertation
    Full Text:
    the amino acid lysine 268, removing the actin binding domain which in-turn abolishes the actin

  • Regulation of phospholipase C-beta isozymes by calmodulin

    Creator:
    McCullar, Jennifer Star
    Abstract:
    Phospholipase C-Jβ (PLCβ) is an important effector enzyme in G-protein-coupled signaling pathways. Activation of PLCβ by Gα and Gβy subunits has been fairly well characterized, but little is known about other protein interactions that may also regulate PLCβ function. A yeast two-hybrid screen of a mouse brain cDNA library with...
    Resource Type:
    Dissertation
    Full Text:
    triphosphate (1P3), a regulator of intracellular calcium, and diacyiglycerol (DAG), a well-characterized

  • Characterization of the response mediated by the plant disease susceptibility gene LOV1

    Creator:
    Gilbert, Brian M.
    Abstract:
    Victoria blight, caused by fungus Cochliobolus victoriae, is a disease originally described on oats and recapitulated on Arabidopsis. Victoria blight is used as a model plant disease that conforms to an inverse gene-for-gene interaction. C. victoriae virulence is dependent upon its production of victorin, a host-specific toxin that induces programmed...
    Resource Type:
    Dissertation
    Full Text:
    effector-triggered immunity. RPP8, the closest homolog to LOV1 (86% similar in amino acid sequence

  • Simple sequence repeat marker development and fingerprinting in Cuphea lanceolata Ait. and C. viscosissima Jacq

    Creator:
    Karmarkar, Vidyadhar M.
    Abstract:
    Microsatellites or simple sequence repeats (SSRs) are highthroughput sequence based DNA markers that have been exploited as tools for measuring genetic distance and diversity in evolutionary studies, protection of intellectual property, genetic resource conservation management, cultivar identification and molecular breeding of crop plants. We isolated and sequenced 1095 clones from...
    Resource Type:
    Masters Thesis
    Full Text:
    . Cuphea has an unmatched profile of fatty acid synthesis rendering it a model system for studying medium