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Filtering by: Creator Bartholomew, Jerri Lee Remove constraint Creator: Bartholomew, Jerri Lee Committee Member Frei, Balz Remove constraint Committee Member: Frei, Balz Resource Type Dissertation Remove constraint Resource Type: Dissertation

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A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:

Monette, Jeffrey S.

Abstract:

Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...

Resource Type:

Dissertation
The aging endoplasmic reticulum

Creator:

Dixon, Brian M.

Abstract:

Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...

Resource Type:

Dissertation
SLC23A1, the gene encoding sodium-dependent vitamin C transport protein 1 (SVCT1) : regulation of transcription and its functional consequences

Creator:

Michels, Alexander Johannes

Abstract:

Vitamin C is an essential component of the human diet. Uptake of vitamin C in the cell is regulated by the function of sodium-dependent vitamin C transporters (SVCTs). SVCT1 (encoded by the SLC23A1 gene) is expressed in the colon, liver and kidney, where it plays a vital role in determining...

Resource Type:

Dissertation
Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:

Shenvi, Swapna V.

Abstract:

Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...

Resource Type:

Dissertation
Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide : pharmacologic administration of lipoic acid partially restores function

Creator:

Smith, Anthony R.

Abstract:

The vascular endothelium is a single cell layer that lines the lumen of the entire vasculature. It is the site of synthesis of nitric oxide (NO), a vasodilatory compound synthesized by endothelial nitric oxide synthase (eNOS). NO causes intracellular calcium sequestration of the vascular smooth muscle cells, relaxing and dilating...

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Dissertation

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Academic Affiliation

Biochemistry and Biophysics2

Advisor

Hagen, Tory M.5

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2005 to 2011

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Committee Member

Frei, Balz[remove]5
Williams, David2
Baird, William1
Beckman, Joe1
Beckman, Joseph1
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Creator

Dixon, Brian M.1
Michels, Alexander Johannes1
Monette, Jeffrey S.1
Shenvi, Swapna V.1
Smith, Anthony R.1

Date

Date range begin – Date range end

Current results range from 2005 to 2011

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Decade

2010-20191
2000-20094

Degree Field

Molecular and Cellular Biology3
Biochemistry and Biophysics2

Degree Level

Doctoral5

Degree Name

Doctor of Philosophy (Ph.D.)5

File Format

application/pdf3

Language

English [eng]5

License

All rights reserved5

Non-Academic Affiliation

Oregon State University. Graduate School5

Peer Reviewed

No5

Resource Type

Dissertation[remove]5

Rights Statement

In Copyright5

Subject

Glutathione -- Physiological effect2
Aging -- Genetic aspects1
Aging -- Nutritional aspects1
Aging -- Physiological aspects1
Carrier proteins1
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