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Filtering by: Creator Michael, Todd P. Remove constraint Creator: Michael, Todd P. Committee Member Freitag, Michael Remove constraint Committee Member: Freitag, Michael Degree Level Doctoral Remove constraint Degree Level: Doctoral

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  • Transcriptomic analysis using high-throughput sequencing and DNA microarrays

    Creator:
    Fox, Samuel E.
    Abstract:
    Transcriptomics and gene expression profiling enables the elucidation of the genetic response of an organism to various environmental cues. Transcriptomics enables the deciphering of differences between two closely related organisms to the same environment and in contrast, enables the elucidation of genetic responses of the same organism to different environmental...
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    Dissertation
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    microarrays. Abstract approved: Todd C. Mockler Transcriptomics and gene expression

  • An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

    Creator:
    Manchanda, Aayushi
    Abstract:
    Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
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    Otoferlin Abstract approved: ______________________________________________________ Colin P

  • Chlamydiae Enhance Self-Antigen Presentation in a Mechanism that is Dependent on Biosynthesis of Lipooligosaccharide

    Creator:
    Cram, Erik D.
    Abstract:
    Chlamydia is a genus of obligate intracellular bacteria that undergo a unique, biphasic developmental cycle. The infectious and metabolically inert Elementary Bodies (EBs) begin the cycle of infection by attaching and invading a host cells. Once inside, the EBs differentiate into the metabolically active, dividing Reticulate Bodies (RBs) within their...
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    scientist and as a person and to whom I look up to. I also want to thank Brian P. Dolan who has been a co

  • Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

    Creator:
    Padgitt-Cobb, Lillian K.
    Abstract:
    Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
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    , which planted seeds for my future research interests. I thank Dr. Todd Michael at the Salk Institute

  • Roles of homeodomain transcription factors during organogenesis

    Creator:
    Xu, Jun
    Abstract:
    The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
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    Dissertation
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    : Chrissa Kioussi Michael K. Gross The spatial and temporal patterning of

  • Perceptions on Spalted Wood: The Influence of Historic Spalting Patterns and Valuation of Spalted Wood Around the World.

    Creator:
    Vega Gutiérrez, Patricia T.
    Abstract:
    During the 1400s – 1600s, spalted wood was an expensive commodity used in marquetry style artworks across primarily Germany and Italy. It fell out of favor during the Industrial Revolution, but is currently experiencing resurgence in popularity with US woodturners. How spalted wood is used, and what types of spalted...
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    Dissertation
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    (Rayner and Todd 1977). Spalting itself is the result of primary and secondary fungal metabolism

  • Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

    Creator:
    Kimbrel, Jeffrey A.
    Abstract:
    Symbiosis is the close and protracted interaction between organisms. The molecular interactions that occur during symbiosis are complex with multiple barriers that must be overcome. Many Gram-negative, host-associated bacteria use a type III secretion system to mediate associations with their eukaryotic hosts. This secretion system is a specialized apparatus for...
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    ................................................................................................... 62   Comparative and phylogenomic analyses of P. fluorescens ..................... 66   Mapping

  • Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

    Creator:
    Hall, Justin Daniel
    Abstract:
    Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
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    , Michael Freitag and Christopher Mathews, I would like to thank Rick Faber and Dale Tronrud for distinct

  • The role of innate immunity in cnidarian-dinoflagellate symbiosis

    Creator:
    Poole, Angela Z.
    Abstract:
    Cnidarians, such as corals and sea anemones serve as hosts to a variety of organisms including symbiotic dinoflagellates, bacteria, virus, and apicomplexans. As corals are vital to the health and productivity of the reef ecosystem it is important to understand how these organisms interact with each component of the holobiont....
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    and teaching endeavors. I would also like to thank Eli Meyer, Michael Freitag, Mike Blouin, Kathy

  • Effects of DNA mismatch repair inhibition in Arabidopsis thaliana

    Creator:
    Wilcox, Buck W. L.
    Abstract:
    Genomic instability underlies diseases of unregulated cell growth that result in cancers and developmental abnormalities in humans. Similar genome destabilizing mechanisms are used to create genetic variety in crops for use in breeding and trait development. Errors that occur during DNA replication may cause mutations if they are not corrected...
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    , and mismatch repair. I would like to thank my committee members, Drs. Michael Freitag, Andrew