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Filtering by: Creator Freilich, Michael H. Remove constraint Creator: Freilich, Michael H. Committee Member Freitag, Michael Remove constraint Committee Member: Freitag, Michael Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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  • Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

    Creator:
    Creason, Allison L.
    Abstract:
    Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
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    Dissertation
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    Rhodococcus Genus. Abstract approved: ______________________________________________________ Jeff H

  • The role of innate immunity in cnidarian-dinoflagellate symbiosis

    Creator:
    Poole, Angela Z.
    Abstract:
    Cnidarians, such as corals and sea anemones serve as hosts to a variety of organisms including symbiotic dinoflagellates, bacteria, virus, and apicomplexans. As corals are vital to the health and productivity of the reef ecosystem it is important to understand how these organisms interact with each component of the holobiont....
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    and teaching endeavors. I would also like to thank Eli Meyer, Michael Freitag, Mike Blouin, Kathy

  • Anaerobic biodegradation of the cyclic nitramines, RDX and HMX, by ovine ruminal microbes

    Creator:
    Eaton, Hillary L.
    Abstract:
    Cyclic nitramines released into all environmental compartments through anthropogenic activities are toxic and possibly carcinogenic and mutagenic. Soils on military ranges, located throughout the world in various climatic regions and close to human activities, are especially susceptible to cyclic nitramine contamination. The properties of soils on military ranges will directly...
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    Dissertation
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    similar compound, in 4 h. In this study, RDX incubated in whole ovine rumen fluid was nearly eliminated

  • Roles of homeodomain transcription factors during organogenesis

    Creator:
    Xu, Jun
    Abstract:
    The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
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    Dissertation
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    : Chrissa Kioussi Michael K. Gross The spatial and temporal patterning of

  • Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

    Creator:
    Padgitt-Cobb, Lillian K.
    Abstract:
    Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
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    Dissertation
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    committee for their valuable guidance: Drs. David Hen- drix, John Henning, Michael Freitag, Maria Clara

  • Prostate cancer prevention with broccoli : from cellular to human studies

    Creator:
    Clarke, John D.
    Abstract:
    Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
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    Dissertation
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    or 20 µmoles of SFN, and SFN metabolites were detected in all tissues tested at 2 and 6 h in a dose

  • Analyses of noncanonical DNA structures

    Creator:
    Khuu, Patricia A.
    Abstract:
    The structural polymorphic nature of DNA has been long been recognized since the model of the right-handed B-DNA duplex proposed by James Watson and Francis Crick was accepted. Its malleability is thought to be critical in protein recognition and manipulation. In particular, it can form Holliday junctions, four-way DNA structural...
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    generosity with his computer knowledge and for sharing his love of science. Special thanks Dr. H. Richard

  • In vivo detoxification of acetic acid in Saccharomyces cerevisiae

    Creator:
    Ding, Jun
    Abstract:
    The studies described in this thesis were motivated by ongoing efforts to develop lignocellulosic biomass as an efficient and practical source of renewable energy. Enormous problems complicate these efforts to reduce reliance on greenhouse gas-generating fossil fuels. Simply obtaining the fermentable sugars available in the cellulose and hemicellulose components of...
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    . I would also like to thank my committee members, Dr. Gary Merrill, Dr. Mike Penner, Dr. Michael

  • The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

    Creator:
    Kyrylkova, Kateryna
    Abstract:
    BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
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    Dissertation
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    confident and successful woman Dr. Michael Freitag, Dr. John Fowler, and Dr. Siva Kolluri, my committee

  • Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

    Creator:
    Hall, Justin Daniel
    Abstract:
    Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
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    , Michael Freitag and Christopher Mathews, I would like to thank Rick Faber and Dale Tronrud for distinct