Index Catalog // ScholarsArchive@OSU

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation
Full Text:: : David A. Hendrix Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an exten

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

Creator:: Kimbrel, Jeffrey A.
Abstract:: Symbiosis is the close and protracted interaction between organisms. The molecular interactions that occur during symbiosis are complex with multiple barriers that must be overcome. Many Gram-negative, host-associated bacteria use a type III secretion system to mediate associations with their eukaryotic hosts. This secretion system is a specialized apparatus for...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Jeffrey A. Kimbrel for the degree of Doctor of Philosophy in Molecular and Cellular

Calpain 2 proteolysis regulates glioblastoma cell invasion

Creator:: Lal, Sangeet Kumar
Abstract:: Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
Resource Type:: Dissertation
Full Text:: Glioblastoma Cell Invasion Abstract approved: Jeffrey A. Greenwood Glioblastoma

Analyses of noncanonical DNA structures

Creator:: Khuu, Patricia A.
Abstract:: The structural polymorphic nature of DNA has been long been recognized since the model of the right-handed B-DNA duplex proposed by James Watson and Francis Crick was accepted. Its malleability is thought to be critical in protein recognition and manipulation. In particular, it can form Holliday junctions, four-way DNA structural...
Resource Type:: Dissertation
Full Text:: Patricia A. Khuu for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on June

Influence of the Environment and Morphology on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

Creator:: Koch, Jack C.
Abstract:: Climate change and other anthropogenic impacts are threatening the existence of millions of species around the globe. On western continental boundaries, the large-scale secondary process of upwelling, which brings low pH, deoxygenated, high nutrient seawater to the surface, is compounded by climate change, that together could drive some species to...
Resource Type:: Dissertation
Full Text:: on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation
Full Text:: characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in

Investigating Transcriptional Control of Specialized Gene Expression in Plants

Creator:: Fraser, Valerie N.
Abstract:: Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
Resource Type:: Dissertation
Full Text:: Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial

Experimental Evolution of Roundup Resistance in Outcrossing Populations of Saccharomyces cerevisiae

Creator:: Hanson, Chloe C.
Abstract:: Evolve & Resequence (E&R) experiments subject laboratory populations to environments controlled by investigators, who then document the phenotypic and genomic changes that take place over many generations. These experiments provide powerful tools for testing of a wide variety of evolutionary questions, especially questions about the nature of adaptive traits. While...
Resource Type:: Masters Thesis
Full Text:: Phillips for taking the time to discuss analysis methods and sharing coding techniques. A final thanks to

Transcriptomic analysis using high-throughput sequencing and DNA microarrays

Creator:: Fox, Samuel E.
Abstract:: Transcriptomics and gene expression profiling enables the elucidation of the genetic response of an organism to various environmental cues. Transcriptomics enables the deciphering of differences between two closely related organisms to the same environment and in contrast, enables the elucidation of genetic responses of the same organism to different environmental...
Resource Type:: Dissertation
Full Text:: relatively new and protocols must be developed for the analyses of transcriptomes (RNA- sequencing). A RNA

Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

Creator:: Creason, Allison L.
Abstract:: Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
Resource Type:: Dissertation
Full Text:: growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted

ScholarsArchive@OSU

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

Calpain 2 proteolysis regulates glioblastoma cell invasion

Analyses of noncanonical DNA structures

Influence of the Environment and Morphology on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Investigating Transcriptional Control of Specialized Gene Expression in Plants

Experimental Evolution of Roundup Resistance in Outcrossing Populations of Saccharomyces cerevisiae

Transcriptomic analysis using high-throughput sequencing and DNA microarrays

Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

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