Index Catalog // ScholarsArchive@OSU

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation
Full Text:: : David A. Hendrix Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an exten

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

Creator:: Kimbrel, Jeffrey A.
Abstract:: Symbiosis is the close and protracted interaction between organisms. The molecular interactions that occur during symbiosis are complex with multiple barriers that must be overcome. Many Gram-negative, host-associated bacteria use a type III secretion system to mediate associations with their eukaryotic hosts. This secretion system is a specialized apparatus for...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Jeffrey A. Kimbrel for the degree of Doctor of Philosophy in Molecular and Cellular

Calpain 2 proteolysis regulates glioblastoma cell invasion

Creator:: Lal, Sangeet Kumar
Abstract:: Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
Resource Type:: Dissertation
Full Text:: Glioblastoma Cell Invasion Abstract approved: Jeffrey A. Greenwood Glioblastoma

Influence of the Environment and Morphology on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

Creator:: Koch, Jack C.
Abstract:: Climate change and other anthropogenic impacts are threatening the existence of millions of species around the globe. On western continental boundaries, the large-scale secondary process of upwelling, which brings low pH, deoxygenated, high nutrient seawater to the surface, is compounded by climate change, that together could drive some species to...
Resource Type:: Dissertation
Full Text:: on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation
Full Text:: characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in

Investigating Transcriptional Control of Specialized Gene Expression in Plants

Creator:: Fraser, Valerie N.
Abstract:: Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
Resource Type:: Dissertation
Full Text:: Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial

Experimental Evolution of Roundup Resistance in Outcrossing Populations of Saccharomyces cerevisiae

Creator:: Hanson, Chloe C.
Abstract:: Evolve & Resequence (E&R) experiments subject laboratory populations to environments controlled by investigators, who then document the phenotypic and genomic changes that take place over many generations. These experiments provide powerful tools for testing of a wide variety of evolutionary questions, especially questions about the nature of adaptive traits. While...
Resource Type:: Masters Thesis
Full Text:: Phillips for taking the time to discuss analysis methods and sharing coding techniques. A final thanks to

Transcriptomic analysis using high-throughput sequencing and DNA microarrays

Creator:: Fox, Samuel E.
Abstract:: Transcriptomics and gene expression profiling enables the elucidation of the genetic response of an organism to various environmental cues. Transcriptomics enables the deciphering of differences between two closely related organisms to the same environment and in contrast, enables the elucidation of genetic responses of the same organism to different environmental...
Resource Type:: Dissertation
Full Text:: relatively new and protocols must be developed for the analyses of transcriptomes (RNA- sequencing). A RNA

Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

Creator:: Creason, Allison L.
Abstract:: Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
Resource Type:: Dissertation
Full Text:: growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Creator:: Codding, Sara Jone
Abstract:: The focus of this dissertation was to understand protein function and structure ona molecular level. To do this successfully, a variety of biochemical and biophysicaltechniques were employed. A wide variety of techniques were applied to study theproteins of interest in this dissertation to probe protein-protein interactions, proteinfunction, protein structure, and...
Resource Type:: Dissertation
Full Text:: and structure on a molecular level. To do this successfully, a variety of biochemical and

Toxicity of Fungal Pigments from Chlorociboria spp. and Scytalidium spp.

Creator:: Almurshidi, Badria H.
Abstract:: Commercial methodologies for producing fungal pigments are of worldwide interest due to the desire to move away from synthetic dyes. Chlorociboria species and Scytalidium species have been reported to produce sufficient yields of pigments for commercial production and have attracted special attention because of their use in spalted wood applications....
Resource Type:: Masters Thesis
Full Text:: reproduce the pigments for commercial use (Phillips 1987; Robinson et al. 2007-a; Robinson et al., 2010-b

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: toxicity information available. Assessing such a large number of chemicals using traditional methods

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:: Goodale, Britton C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
Resource Type:: Dissertation
Full Text:: this large family of multi-ring structures and substituted derivatives is a substantial challenge

The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

Creator:: Kyrylkova, Kateryna
Abstract:: BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
Resource Type:: Dissertation
Full Text:: century. Nat Rev Genet 6, 507-12. Cavenee, W. K., Dryja, T. P., Phillips, R. A., Benedict, W. F

The role of innate immunity in cnidarian-dinoflagellate symbiosis

Creator:: Poole, Angela Z.
Abstract:: Cnidarians, such as corals and sea anemones serve as hosts to a variety of organisms including symbiotic dinoflagellates, bacteria, virus, and apicomplexans. As corals are vital to the health and productivity of the reef ecosystem it is important to understand how these organisms interact with each component of the holobiont....
Resource Type:: Dissertation
Full Text:: as corals and sea anemones serve as hosts to a variety of organisms including symbiotic

Perceptions on Spalted Wood: The Influence of Historic Spalting Patterns and Valuation of Spalted Wood Around the World.

Creator:: Vega Gutiérrez, Patricia T.
Abstract:: During the 1400s – 1600s, spalted wood was an expensive commodity used in marquetry style artworks across primarily Germany and Italy. It fell out of favor during the Industrial Revolution, but is currently experiencing resurgence in popularity with US woodturners. How spalted wood is used, and what types of spalted...
Resource Type:: Dissertation
Full Text:: and marquetry works and developing a method for determining the presence of spalted wood so that the

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Creator:: Hall, Justin Daniel
Abstract:: Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
Resource Type:: Dissertation
Full Text:: multivalency between Tctex1 and LC8 results in a 50-fold affinity enhancement for IC binding despite no

ScholarsArchive@OSU

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

Calpain 2 proteolysis regulates glioblastoma cell invasion

Influence of the Environment and Morphology on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Investigating Transcriptional Control of Specialized Gene Expression in Plants

Experimental Evolution of Roundup Resistance in Outcrossing Populations of Saccharomyces cerevisiae

Transcriptomic analysis using high-throughput sequencing and DNA microarrays

Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Toxicity of Fungal Pigments from Chlorociboria spp. and Scytalidium spp.

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

The role of innate immunity in cnidarian-dinoflagellate symbiosis

Perceptions on Spalted Wood: The Influence of Historic Spalting Patterns and Valuation of Spalted Wood Around the World.

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

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