Index Catalog // ScholarsArchive@OSU

Bioactivity Screening and Gene Activation Strategies in Fungi

Creator:: Coddington, Nathan C.
Abstract:: Natural products from plants, bacteria, and fungi play an important role in society. Over the last 35 years, natural products and their derivatives have inspired over 60% of all FDA approved small-molecule drugs, and are among the top prescribed therapeutics.1-2 Fleming’s discovery of the fungal antibiotic penicillin started the “Golden...
Resource Type:: Honors College Thesis
Full Text:: Strategies in Fungi By Nathan Charles Coddington A PROJECT Submitted to

The role of innate immunity in cnidarian-dinoflagellate symbiosis

Creator:: Poole, Angela Z.
Abstract:: Cnidarians, such as corals and sea anemones serve as hosts to a variety of organisms including symbiotic dinoflagellates, bacteria, virus, and apicomplexans. As corals are vital to the health and productivity of the reef ecosystem it is important to understand how these organisms interact with each component of the holobiont....
Resource Type:: Dissertation
Full Text:: along their knowledge of many lab protocols. I thank Nathan Kirk for his assistance with the LCM

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation
Full Text:: admiration for my cohort: Nathan Waugh, Allyson Erlendson, Shauna Otto, and Riley Bednar. I am grateful for

Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

Creator:: Creason, Allison L.
Abstract:: Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
Resource Type:: Dissertation
Full Text:: al., 2001; Putnam and Miller, 2007). PLANT HORMONE BIOSYNTHESIS AND PERCEPTION Plant hormones

Calpain 2 proteolysis regulates glioblastoma cell invasion

Creator:: Lal, Sangeet Kumar
Abstract:: Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
Resource Type:: Dissertation
Full Text:: Ladu for the training of zebrafish microinjections. I thank Nathan Lopez for help in the mouse brain

Growth, morphology, and in vitro development of transgenic poplars with RNAi-inhibited PtDDM1-1/2 gene expression

Creator:: Zhu, Ruoqing
Abstract:: Epigenetic mechanisms are important for control of plant development, and may play a particularly important role in trees given their long life cycles and distinctive and stable tissue types. To help understand the role of epigenetics in tree development, we produced transgenic poplars with reduced activity of the DDM1 genes,...
Resource Type:: Masters Thesis

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Creator:: Hall, Justin Daniel
Abstract:: Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
Resource Type:: Dissertation
Full Text:: foundation for financial assistance. CONTRIBUTION OF AUTHORS Nathan Pursifull contributed to

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Creator:: Shorey, Lyndsey E.
Abstract:: Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Resource Type:: Dissertation

Influence of the Environment and Morphology on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

Creator:: Koch, Jack C.
Abstract:: Climate change and other anthropogenic impacts are threatening the existence of millions of species around the globe. On western continental boundaries, the large-scale secondary process of upwelling, which brings low pH, deoxygenated, high nutrient seawater to the surface, is compounded by climate change, that together could drive some species to...
Resource Type:: Dissertation

Transcriptomic analysis using high-throughput sequencing and DNA microarrays

Creator:: Fox, Samuel E.
Abstract:: Transcriptomics and gene expression profiling enables the elucidation of the genetic response of an organism to various environmental cues. Transcriptomics enables the deciphering of differences between two closely related organisms to the same environment and in contrast, enables the elucidation of genetic responses of the same organism to different environmental...
Resource Type:: Dissertation
Full Text:: . .......................................................................................................................261 Appendix VI: Figure 1. Anchoring the F. vesca genome to the diploid Fragaria reference map, FV

ScholarsArchive@OSU

Bioactivity Screening and Gene Activation Strategies in Fungi

The role of innate immunity in cnidarian-dinoflagellate symbiosis

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

Calpain 2 proteolysis regulates glioblastoma cell invasion

Growth, morphology, and in vitro development of transgenic poplars with RNAi-inhibited PtDDM1-1/2 gene expression

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Influence of the Environment and Morphology on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

Transcriptomic analysis using high-throughput sequencing and DNA microarrays

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